Identifiers
ferrochelatase
HUGO:FECH HGNC:3647 ENTREZ:2235 UNIPROT:P22830

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death   / ANTIOXIDANT_RESPONSE 
 Regulated Cell Death   / MITOCHONDRIAL_METABOLISM 
 Regulated Cell Death   / PORPHYRIN_METABOLISM 
 RECON2 

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death   / ANTIOXIDANT_RESPONSE 
 Regulated Cell Death   / MITOCHONDRIAL_METABOLISM 
 Regulated Cell Death   / PORPHYRIN_METABOLISM 

References
rc_re834( Regulated Cell Death  ):
PMID:7544575
in vitro
in RAW 264.7 upon NOS2 induction (LPS+IFNg)
proposed mechanise: loss of iron sulfur cluster

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death   / ANTIOXIDANT_RESPONSE 
 Regulated Cell Death   / MITOCHONDRIAL_METABOLISM 
 Regulated Cell Death   / PORPHYRIN_METABOLISM 

References
rc_re833( Regulated Cell Death  ):
PMID:10561552
caracterization of human ferrochelatase as a Fe-S homodimer
PMID:16839620
review heme biosynthesis in mammals
rc_re834( Regulated Cell Death  ):
PMID:7544575
in vitro
in RAW 264.7 upon NOS2 induction (LPS+IFNg)
proposed mechanise: loss of iron sulfur cluster

1. FECH@Mitochondrial intermembrane space
2. FECH|​hm2|​[2FE-2S]@Mitochondrial intermembrane space

1. FECH|​hm2|​[2FE-2S]@Mitochondrial intermembrane space + NO@Mitochondrial intermembrane space → FECH@Mitochondrial intermembrane space
2. rFECH@Nucleus → FECH@Mitochondrial intermembrane space
3. FECH@Mitochondrial intermembrane space → FECH|​hm2|​[2FE-2S]@Mitochondrial intermembrane space

1. protoporphyrin IX@Mitochondrial intermembrane space + Fe2+@Mitochondrial intermembrane space → ferroheme b@Mitochondrial intermembrane space + H+@Mitochondrial intermembrane space