Protein CDC42_GEFs* map

Identifiers
CDC42_GEFs*
epithelial cell transforming sequence 2 oncogene
HUGO:ECT2, HGNC:3155, ENTREZ:1894, GENECARDS:GC03P172468, UNIPROT:Q9H8V3
MCF.2 cell line derived transforming sequence
HUGO:MCF2 HGNC:6940 ENTREZ:4168 UNIPROT:P10911
differentially expressed in FDCP 6 homolog (mouse)
HUGO:DEF6 HGNC:2760 ENTREZ:50619 UNIPROT:Q9H4E7
FYVE, RhoGEF and PH domain containing 1
"faciogenital dysplasia (Aarskog-Scott syndrome)", FGDY
HUGO:FGD1 HGNC:3663 ENTREZ:2245 UNIPROT:P98174
FYVE, RhoGEF and PH domain containing 4
"FGD1 family, member 4"
HUGO:FGD4 HGNC:19125 ENTREZ:121512 UNIPROT:Q96M96
dedicator of cytokinesis 6
HUGO:DOCK6 HGNC:19189 ENTREZ:57572 UNIPROT:Q96HP0
dedicator of cytokinesis 9
HUGO:DOCK9 HGNC:14132 ENTREZ:23348 UNIPROT:Q9BZ29
dedicator of cytokinesis 11
HUGO:DOCK11 HGNC:23483 ENTREZ:139818 UNIPROT:Q5JSL3
spermatogenesis associated 13
HUGO:SPATA13 HGNC:23222 ENTREZ:221178 UNIPROT:Q96N96

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CYTOSKELETON_POLARITY  map

References
GEFs are essential for CDC42 activation. They promote the exchange of GDP to GTP to generate the activated form of CDC42 capable of recognizing downstram targets.
PMID:8836113

CDC42_GEFs*@Cytosol

References
em_emtc_emtc_re844( EMT Senescence  map ):
PMID:10816584
PMID:17045588
CDC42SE1 (SPEC1) binds to CDC42 and supresses CDC42-induced JNK activation and cytoskeleton remodeling.
PMID:9113980
RhoGDI (so-called ARHGDIA) and GDIG4 (so-called ARHGDIB) are two known GDIs for the Rho-subfamily of GTPases.
ARHGDIG is about 50 percent identical to ARHGDIA and ARHGDIB. ARHGFIG binds to CDC42 and RhoA with less affinity compared with ARHGDIA and does not bind with Rac1, Rac2, or Ras.
ARHGDIG functions as a GDI for CDC42 but with about 20 times less efficiency than ARHGDIA.
PMID:9490022
ARHGDIA,B,G are CDC42_GDIs
em_emtc_emtc_re884( EMT Senescence  map ):
PMID:8836113
GEFs are essential for CDC42 activation. They promote the exchange of GDP to GTP to generate the activated form of CDC42 capable of recognizing downstram targets.
PMID:15743413
PMID:11429692
FGD1,4 are GEFs of CDC42
em_emtc_emtc_re886( EMT Senescence  map ):
PMID:15247287
PMID:16968698
PMID:17196961
DOCK6,9,11 as a GEF of CDC42
em_emtc_emtc_re889( EMT Senescence  map ):
PMID:17145773
SPATA13 (Asef2) as a GEF of CDC42
em_emtc_emtc_re890( EMT Senescence  map ):
PMID:10579713
ARHGEF31 as a GEF of CDC42
em_emtc_emtc_re891( EMT Senescence  map ):
PMID:10843989
MCF2 (DBL) as a GEF of CDC42
PMID:11394904
PMID:10652228
GEF activity of MCF2 (DBL) towards CDC42 or Rac1 is enhanced upon TNK2 (ACK1) phosphorylation.
em_emtc_emtc_re892( EMT Senescence  map ):
PMID:15023524
DEF6 as a GEF of CDC42
em_emtc_emtc_re893( EMT Senescence  map ):
PMID:11889037
ARHGAP14 (MCF2L or DBS) as a GEF of CDC42

Modifications:
In compartment: Cytosol
  1. CDC42_GEFs*@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. CDC42_GEFs*@Cytosol map → map FGD1@Cytosol map
    2. CDC42_GEFs*@Cytosol map → map FGD4@Cytosol map
    3. CDC42_GEFs*@Cytosol map → map DOCK6@Cytosol map
    4. CDC42_GEFs*@Cytosol map → map DOCK9@Cytosol map
    5. CDC42_GEFs*@Cytosol map → map DOCK11@Cytosol map
    6. CDC42_GEFs*@Cytosol map → map SPATA13@Cytosol map
    7. CDC42_GEFs*@Cytosol map → map ARHGEF31*@Cytosol map
    8. CDC42_GEFs*@Cytosol map → map MCF2|​pho|​active@Cytosol map
    9. CDC42_GEFs*@Cytosol map → map DEF6@Cytosol map
    10. CDC42_GEFs*@Cytosol map → map ARHGAP14*@Cytosol map
    As Catalyser:
    1. em_emtc_emtc_s3012 → map em_emtc_emtc_s3011