Reaction state_transition em_emtc_emtc_re844 map

em_emtc_emtc_s3012 → em_emtc_emtc_s3011

Reaction regulators:
Catalysis
  1. CDC42_GEFs*@Cytosol map
Inhibition
  1. CDC42SE1@Cytosol map
  2. RhoA_and_CDC42_GDIs*@Cytosol map


References
PMID:10816584
PMID:17045588
CDC42SE1 (SPEC1) binds to CDC42 and supresses CDC42-induced JNK activation and cytoskeleton remodeling.
PMID:9113980
RhoGDI (so-called ARHGDIA) and GDIG4 (so-called ARHGDIB) are two known GDIs for the Rho-subfamily of GTPases.
ARHGDIG is about 50 percent identical to ARHGDIA and ARHGDIB. ARHGFIG binds to CDC42 and RhoA with less affinity compared with ARHGDIA and does not bind with Rac1, Rac2, or Ras.
ARHGDIG functions as a GDI for CDC42 but with about 20 times less efficiency than ARHGDIA.
PMID:9490022
ARHGDIA,B,G are CDC42_GDIs