Identifiers
ZO1_3*
tight junction protein 1
HUGO:TJP1, HGNC:11827, ENTREZ:7082, GENECARDS:GC15M029991, UNIPROT:Q07157??
tight junction protein 3
HUGO:TJP3, HGNC:11829, ENTREZ:27134, GENECARDS:GC19P003659, UNIPROT:O95049
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / CELL_CELL_ADHESIONS
EMT Senescence / TIGHT_JUNCTIONS
References
PMID:Identifiers_end
References
em_emtc_emtc_re663( EMT Senescence ):
PMID:11557048
GJC1 interacts with the PDZ domains of ZO-1 and ZO-3 but not ZO-2
PMID:11313345
Connexin45 (GJC1) interacts with ZO-1 and connexin43 (GJA1) in osteoblastic cells.
em_emtc_emtc_re665( EMT Senescence ):
The growing number of connexins (i.e. Cx43 and Cx45) that can associate with ZO proteins indicate that ZO proteins may play a more general role in organizing gap junctions and/or in recruiting signaling molecules that regulate intercellular communication.