Protein RhoA_GEFs* map

Identifiers
RhoA_GEFs*
Rho guanine nucleotide exchange factor (GEF) 1
HUGO:ARHGEF1, HGNC:681, ENTREZ:9138, GENECARDS:GC19P042387, UNIPROT:Q92888
Rho/Rac guanine nucleotide exchange factor (GEF) 2
HUGO:ARHGEF2, HGNC:682, ENTREZ:9181, GENECARDS:GC01M155916, UNIPROT:Q92974
Rho guanine nucleotide exchange factor (GEF) 3
HUGO:ARHGEF3, HGNC:683, ENTREZ:50650, GENECARDS:GC03M056736, UNIPROT:Q9NR81
Rho guanine nucleotide exchange factor (GEF) 4
HUGO:ARHGEF4, HGNC:684, ENTREZ:50649, GENECARDS:GC02P131595, UNIPROT:Q9NR80
Rho guanine nucleotide exchange factor (GEF) 10-like
HUGO:ARHGEF10L, HGNC:25540, ENTREZ:55160, GENECARDS:GC01P017866, UNIPROT:Q9HCE6
Rho guanine nucleotide exchange factor (GEF) 12
HUGO:ARHGEF12, HGNC:14193, ENTREZ:23365, GENECARDS:GC11P120207, UNIPROT:Q9NZN5
MCF.2 cell line derived transforming sequence-like
HUGO:MCF2L, HGNC:14576, ENTREZ:23263, GENECARDS:GC13P113548, UNIPROT:O15068
neuronal guanine nucleotide exchange factor
HUGO:NGEF, HGNC:7807, ENTREZ:25791 , GENECARDS:GC02M233707 , UNIPROT:Q8N5V2
epithelial cell transforming sequence 2 oncogene
HUGO:ECT2, HGNC:3155, ENTREZ:1894, GENECARDS:GC03P172468, UNIPROT:Q9H8V3
RAP1, GTP-GDP dissociation stimulator 1
HUGO:RAP1GDS1, HGNC:9859, ENTREZ:5910, GENECARDS:GC04P099182, UNIPROT:P52306
vav 2 guanine nucleotide exchange factor
HUGO:VAV2, HGNC:12658, ENTREZ:7410, GENECARDS:GC09M136627, UNIPROT:P52735

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CYTOSKELETON_POLARITY  map

References
PMID:9789025
PMID:9641915
p115RhoGEF(so-called ARHGEF1) is an Rho guanine nucleotide exchange factor.

RhoA_GEFs*@Cytosol

References
em_emtc_emtc_re693( EMT Senescence  map ):
PMID:11149925
2 classes of negative regulators of Rho proteins have been described. GAPs and GDIs.
Rho proteins have relatively slow intrinsic rates of GTP hydrolysis that can be accelerated by GAPs (GTPase activating proteins).
Another class of proteins shown to inhibit the release of GDP from Rho proteins, GDIs (GDP Dissociation Inhibitors (GDIs) have been described.
Perhaps more important than their effects on the GDP/GTP cycle is the ability of GDIs to solubilize membrane-associated Rho proteins.
RhoA is sequestered in the cytosol by a RhoGDI-dependent and -independent mechanisms.
RhoGDI binding is not affected by the length of the prenyl chain (farnesylation versus geranylgeranylation)
Palmitoylation blocks RhoGDI binding.
PMID:9113980
GDIs play a primary role in modulating the activation of GTPases and may also be critical for the cellular compartmentalization of GTPases.
em_emtc_emtc_re734( EMT Senescence  map ):
PMID:16112081
In vitro, GrinchGEF (ARHGEF10L) induced the GDP/ GTP exchange at RhoA, but not at Rac1 or Cdc42.
In intact cells, GrinchGEF induced specifically Rho activation and enhanced RhoA,B,C-specific downstream effect.
GrinchGEF, similar to its relative p164-RhoGEF (ARHGEF17), is a Rho-specific GEF.
Although RhoA, B, and C have different cellular functions, and some regulators and effectors show preferential interaction with these Rho isoforms, GrinchGEF apparently does not distinguish between RhoA,B,C and similarly activates these Rho proteins
em_emtc_emtc_re735( EMT Senescence  map ):
PMID:9822605
Phosphorylated Vav-2 was found to be active on RhoA, RhoB and the more distantly related RhoG protein

Modifications:
In compartment: Cytosol
  1. RhoA_GEFs*@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. RhoA_GEFs*@Cytosol map → map ARHGEF1@Cytosol map
    2. RhoA_GEFs*@Cytosol map → map ARHGEF2@Cytosol map
    3. RhoA_GEFs*@Cytosol map → map ARHGEF3@Cytosol map
    4. RhoA_GEFs*@Cytosol map → map ARHGEF12@Cytosol map
    5. RhoA_GEFs*@Cytosol map → map ARHGEF27*@Cytosol map
    6. RhoA_GEFs*@Cytosol map → map ARHGEF14*@Cytosol map
    7. RhoA_GEFs*@Cytosol map → map RAP1GDS1@Cytosol map
    8. RhoA_GEFs*@Cytosol map → map ARHGEF31*@Cytosol map
    9. RhoA_GEFs*@Cytosol map → map ARHGEF10L@Cytosol map
    10. RhoA_GEFs*@Cytosol map → map VAV2@Cytosol map
    As Catalyser:
    1. em_emtc_emtc_s2907 → map em_emtc_emtc_s2905