Identifiers
Rho guanine nucleotide exchange factor (GEF) 10-like
HUGO:ARHGEF10L, HGNC:25540, ENTREZ:55160, GENECARDS:GC01P017866, UNIPROT:Q9HCE6
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / CYTOSKELETON_POLARITY
References
PMID:16112081
In vitro, GrinchGEF (ARHGEF10L) induced the GDP/ GTP exchange at RhoA, but not at Rac1 or Cdc42.
In intact cells, GrinchGEF induced specifically Rho activation and enhanced RhoA,B,C-specific downstream effect.
GrinchGEF, similar to its relative p164-RhoGEF (ARHGEF17), is a Rho-specific GEF.
Although RhoA, B, and C have different cellular functions, and some regulators and effectors show preferential interaction with these Rho isoforms, GrinchGEF apparently does not distinguish between RhoA,B,C and similarly activates these Rho proteins
References
em_emtc_emtc_re732( EMT Senescence ):
PMID:16112081
In vitro, GrinchGEF (ARHGEF10L) induced the GDP/ GTP exchange at RhoA, but not at Rac1 or Cdc42.
In intact cells, GrinchGEF induced specifically Rho activation and enhanced RhoA,B,C-specific downstream effect.
GrinchGEF, similar to its relative p164-RhoGEF (ARHGEF17), is a Rho-specific GEF.
Although RhoA, B, and C have different cellular functions, and some regulators and effectors show preferential interaction with these Rho isoforms, GrinchGEF apparently does not distinguish between RhoA,B,C and similarly activates these Rho proteins