Protein CDK5 map

Identifiers
cyclin-dependent kinase 5
HUGO:CDK5 HGNC:1774 ENTREZ:1020 UNIPROT:Q00535
HUGO:CDK5 hgnc_id:HGNC:1774 HGNC:1774 ENTREZ:1020 UNIPROT:Q00535

Maps_Modules
HMC:GENOME_INSTABILITY_AND_MUTATION
 Cell Cycle DNA Repair  map  / BER  map
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / ER_STRESS  map

References
Triple phosphorylation by CDK5 inhibits PARP1
PMID:21922195
Stabilisation of USP1 by phosphorylaton by CDK5
PMID:23589330
PMID:23850759

CDK5@Nucleus

References
ce_re36( Cell Cycle DNA Repair  map ):
PMID:16332722
Auto-phosphorylation of ATM in response to DNA DSB:
PMID:17303408, PMID:12556884, PMID:16858402
Amplification of ATM auto-phosphorylation by the complex ATM:MRNcomplex:H2AX:MDC1CDK5 phosphorylates and activates ATM
PMID:19151707
ce_re554:( Cell Cycle DNA Repair  map ) PMID:21727086, PMID:21922195, PMID:20724832
ce_re555( Cell Cycle DNA Repair  map ):
Triple phosphorylation by CDK5 inhibits PARP1
PMID:21922195
ce_re565( Cell Cycle DNA Repair  map ):
Stabilisation by phosphorylaton by CDK5
PMID:23589330

Modifications:
In compartment: Cytosol
  1. CDK5@Cytosol map
In compartment: Nucleus
  1. CDK5@Nucleus map
Participates in complexes:
In compartment: Nucleus
  1. CDK5:​EME1:​STAT3|​Ser727_pho@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. EME1@Nucleus map + STAT3|​Ser727_pho@Nucleus map + CDK5@Nucleus map → map CDK5:​EME1:​STAT3|​Ser727_pho@Nucleus map
  2. CDK5@Cytosol map → map CDK5@Cytosol map
As Catalyser:
  1. gHR_DNA_st5*@Nucleus map → map gHR_DNA_st6*@Nucleus map
  2. ATM@Nucleus map → map ATM|​S1981_pho|​S367_pho|​S1893_pho|​active@Nucleus map
  3. APE*@Nucleus map → map APE*|​Thr233_pho|​ubi@Nucleus map
  4. PARP1@Nucleus map → map PARP1|​Ser782_pho|​Ser786_pho|​Ser785_pho@Nucleus map
  5. USP1@Nucleus map → map USP1|​pho@Nucleus map
  6. MAP3K4@Cytosol map → map MAP3K4|​pho@Cytosol map