Protein USP1
Identifiers
ubiquitin specific peptidase 1
HUGO:USP1, HGNC:12607, ENTREZ:7398, UNIPROT:O94782
Maps_Modules
HMC:GENOME_INSTABILITY_AND_MUTATION
Cell Cycle DNA Repair
/ FANCONI
Cell Cycle DNA Repair
/ TLS
References
PMID:19686080, PMID:19622404, PMID:18931676
Stabilisation by phosphorylaton by CDK5
PMID:23589330
USP1|pho@Nucleus
References
ce_re565( Cell Cycle DNA Repair
):
Stabilisation by phosphorylaton by CDK5
PMID:23589330
ce_re193( Cell Cycle DNA Repair
):
USP1 levles are cell cycle regulated USP1 is at the peak during early G1/S phase and declines late S/G2 phase.
PMID:19264559
USP1@Nucleus
References
ce_re565( Cell Cycle DNA Repair
):
Stabilisation by phosphorylaton by CDK5
PMID:23589330
Modifications:
In compartment: Nucleus
- USP1@Nucleus
- USP1|pho@Nucleus
Participates in complexes:
In compartment: Nucleus
- UAF1*:USP1|pho@Nucleus
Participates in reactions:
As Reactant or Product:- USP1|pho@Nucleus
+ UAF1*@Nucleus
→
UAF1*:USP1|pho@Nucleus
- USP1|pho@Nucleus
→
degraded
- rUSP1@Nucleus
→
USP1|pho@Nucleus
- USP1@Nucleus
→
USP1|pho@Nucleus
As Catalyser:- FANCI|K523_ubi|pho@Nucleus
→
FANCI|pho@Nucleus
- FANCD2|K561_ubi|pho@Nucleus
→
FANCD2|pho@Nucleus
- PCNA|K164_ubi@Nucleus
→
PCNA@Nucleus
- BRCA1:BRCA2:FANCD2|K561_ubi|pho:FANCI|K523_ubi|pho:H2AFX|S139_pho|ubi:NBS1*|S343_pho:PCNA:RAD51:TIP60*@Nucleus
→
BRCA1:BRCA2:FANCD2|pho:FANCI|pho:H2AFX|S139_pho|ubi:NBS1*|S343_pho:PCNA:RAD51:TIP60*@Nucleus
- BRCA1:BRCA2:FANCD2|K561_ubi|pho:FANCI|K523_ubi|pho:FANCJ*:FANCN*@Nucleus
→
BRCA1:BRCA2:FANCD2|pho:FANCI|pho:FANCJ*:FANCN*@Nucleus