Protein MAP3K4 map

Identifiers
mitogen-activated protein kinase kinase kinase 4
HUGO:MAP3K4 hgnc_id:HGNC:6856 HGNC:6856 ENTREZ:4216 UNIPROT:Q9Y6R4
MEKK4
HUGO:MAP3K4 HGNC:6856 ENTREZ:4216 UNIPROT:Q9Y6R4

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / TCR_SIGNALING  map
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / ER_STRESS  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / MAPK  map

References
PMID:24104473 PMID:16799472 PMID:11175814
PMID:23850759
MEKK4 is a MAP3K and can activate both JNK and P38 pathways. It may be an effector for stress pathways activated by genotoxins.
PMID:11274345

MAP3K4@Cytoplasm

References
su_mpk1_mpk1_re143( Survival  map ):
Expression of GADD45 genes in mammalian cells strongly activates co-expressed MTK1 as well as P38 and JNK the MAPKs downstream of MTK1.
GADD45alpha/beta are direct MEKK4 interactors. They are involved in genotoxin regulation of MEKK4 signalling to JNK and P38
PMID:21614932 PMID:11274345

Modifications:
In compartment: Cytoplasm
  1. MAP3K4@Cytoplasm map
In compartment: Cytosol
  1. MAP3K4@Cytosol map
  2. MAP3K4|​pho@Cytosol map
In compartment: T_cell
  1. MAP3K4@T_cell map
Participates in complexes:
In compartment: Cytoplasm
  1. GADD45*:​MAP3K4|​pho@Cytoplasm map
Participates in reactions:
As Reactant or Product:
  1. MAP3K4@T_cell map → map MAP3K4@T_cell map
  2. MAP3K4@Cytosol map → map MAP3K4|​pho@Cytosol map
  3. GADD45*@Cytoplasm map + MAP3K4@Cytoplasm map → map GADD45*:​MAP3K4|​pho@Cytoplasm map
As Catalyser:
  1. MAP2K4@T_cell map → map MAP2K4|​pho@T_cell map
  2. MAP2K3@T_cell map → map MAP2K3|​pho@T_cell map
  3. MAP2K6@T_cell map → map MAP2K6|​pho@T_cell map
  4. JNK1*@Cytosol map → map JNK1*|​pho|​active@Cytosol map
  5. MAP2K4@Cytoplasm map → map MAP2K4|​pho|​pho@Cytoplasm map
  6. MAP2K3@Cytoplasm map → map MAP2K3|​pho|​pho@Cytoplasm map
  7. MAP2K6@Cytoplasm map → map MAP2K6|​pho|​pho@Cytoplasm map