Protein CRKL map

Identifiers
HUGO:CRKL

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CORE_PATHWAYS  map

References
PMID:16076871
 NATURAL_KILLER  map
CASCADE:NKG2D
PMID:19454690, PMID:18835194
CrkL suppression resulted in a significant decrease in cytotoxicity against P815 tumor targets coated with either anti-NKG2D or anti-FcR, and against MICA-expressing BaF3 cells.
But at the same time,CrkL was shown to be phosphorylated in an Abl-dependent manner upon ligation of inhibitory killer Ig-related receptors (KIRs) to terminate signaling from activating receptors.

Modifications:
In compartment: Cytosol
  1. CRKL@Cytosol map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. CRKL@INNATE_IMMUNE_CELL_Cytosol map
  2. CRKL|​pho@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. CRK:​CRKL:​FIGF:​FLT4:​FLT4|​Y1063_pho|​Y1337_pho|​Y1230_pho:​GRB2:​NRP2:​SHC1:​VEGFC@Cytosol map
  2. CRK:​CRKL:​FIGF:​FLT4|​Y1230_pho|​Y1063_pho:​KDR|​Y1175_emp|​1054_pho:​NRP1:​NRP2:​VEGFA:​VEGFB:​VEGFC@Cytosol map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. CRKL:​PI3KR(p85)*@INNATE_IMMUNE_CELL_Cytosol map
  2. (BCAR1|​pho:​CBL|​pho:​CRK:​CRKL:​RAPGEF1)|​active@INNATE_IMMUNE_CELL_Cytosol map
  3. BCAR1|​pho:​CBL|​pho:​CRKL|​pho:​CRK|​pho:​RAPGEF1@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. FIGF:​KDR:​NRP1:​VEGFC@Cytosol map + FIGF:​FLT4:​NRP2:​VEGFC@Cytosol map + CRKL@Cytosol map + CRK@Cytosol map + VEGFA:​VEGFB@Extracellular Matrix map → map CRK:​CRKL:​FIGF:​FLT4|​Y1230_pho|​Y1063_pho:​KDR|​Y1175_emp|​1054_pho:​NRP1:​NRP2:​VEGFA:​VEGFB:​VEGFC@Cytosol map
  2. FIGF:​FLT4:​NRP2:​VEGFC@Cytosol map → map CRK:​CRKL:​FIGF:​FLT4:​FLT4|​Y1063_pho|​Y1337_pho|​Y1230_pho:​GRB2:​NRP2:​SHC1:​VEGFC@Cytosol map
  3. CRK:​CRKL:​FIGF:​FLT4:​FLT4|​Y1063_pho|​Y1337_pho|​Y1230_pho:​GRB2:​NRP2:​SHC1:​VEGFC@Cytosol map → map PKC activation@Cytosol map
  4. CRKL@INNATE_IMMUNE_CELL_Cytosol map + PI3KR(p85)*@INNATE_IMMUNE_CELL_Cytosol map → map CRKL:​PI3KR(p85)*@INNATE_IMMUNE_CELL_Cytosol map
  5. (BCAR1|​pho:​CBL|​pho:​CRK:​CRKL:​RAPGEF1)|​active@INNATE_IMMUNE_CELL_Cytosol map → map BCAR1|​pho:​CBL|​pho:​CRKL|​pho:​CRK|​pho:​RAPGEF1@INNATE_IMMUNE_CELL_Cytosol map
  6. BCAR1@INNATE_IMMUNE_CELL_Cytosol map + RAPGEF1@INNATE_IMMUNE_CELL_Cytosol map + CBL|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map + CRK@INNATE_IMMUNE_CELL_Cytosol map + CRKL@INNATE_IMMUNE_CELL_Cytosol map → map (BCAR1|​pho:​CBL|​pho:​CRK:​CRKL:​RAPGEF1)|​active@INNATE_IMMUNE_CELL_Cytosol map
  7. BCAR1|​pho:​CBL|​pho:​CRKL|​pho:​CRK|​pho:​RAPGEF1@INNATE_IMMUNE_CELL_Cytosol map → map RAPGEF1@INNATE_IMMUNE_CELL_Cytosol map + BCAR1@INNATE_IMMUNE_CELL_Cytosol map + CBL|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map + CRK|​pho@INNATE_IMMUNE_CELL_Cytosol map + CRKL|​pho@INNATE_IMMUNE_CELL_Cytosol map + CRKL@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. MAP2K4@Cytosol map → map MAP2K4|​pho@Cytosol map
  2. PIK3R1:​PIK3R2@Cytosol map → map PIK3R1|​pho:​PIK3R2@Cytosol map
  3. CREB*@Cytosol map → map CREB*|​S133_pho@Cytosol map
  4. GDP:​RAP1A@INNATE_IMMUNE_CELL_Cytosol map + GTP@INNATE_IMMUNE_CELL_Cytosol map → map (GTP:​RAP1A)|​active@INNATE_IMMUNE_CELL_Cytosol map + GDP@INNATE_IMMUNE_CELL_Cytosol map
  5. BCAR1@INNATE_IMMUNE_CELL_Cytosol map + RAPGEF1@INNATE_IMMUNE_CELL_Cytosol map + CBL|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map + CRK@INNATE_IMMUNE_CELL_Cytosol map + CRKL@INNATE_IMMUNE_CELL_Cytosol map → map (BCAR1|​pho:​CBL|​pho:​CRK:​CRKL:​RAPGEF1)|​active@INNATE_IMMUNE_CELL_Cytosol map