Identifiers
Src family kinases*
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
HUGO:SRC, HGNC:11283, ENTREZ:6714, UNIPROT:P12931, GENECARDS:GC20P035973
c-src tyrosine kinase
HUGO:CSK HGNC:2444 ENTREZ:1445 UNIPROT:P41240
FYN oncogene related to SRC, FGR, YES
HUGO:FYN HGNC:4037 ENTREZ:2534 UNIPROT:P06241
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / CELL_CELL_ADHESIONS
EMT Senescence / GAP_JUNCTIONS
EMT Senescence / ADHERENS_JUNCTIONS
EMT Senescence / CYTOSKELETON_POLARITY
EMT Senescence / CELL_MATRIX_ADHESIONS
References
PMID:16492141
Binding partners proteins of Connexin 43 (GJA1):
-Kinases: v-Src, c-Src, PKC, PKA, MAPK, Casein kinase 1, Cdc2 kinase
-TIGHT_JUNCTIONS scaffold proteins: ZO1, ZO2, caveolin 1
-Cytoskeleton: b-catenin, a-tubulin, b-tubulin
-Others: Drebrin, NOV, CIP85
PMID:9278444
Reduction of gap junctional communication in v-src transformed cells is accompanied by tyrosine phosphorylation of the gap junction protein, connexin 43
SH3 and SH2 domains of v-Src bind to proline-rich motifs and a phosphorylated tyrosine residue in the C-terminal tail of Cx43
PMID:9592087
Cx32 (GJB1) interacts with Cx26(GJB2), Cx46(GJA3), and Cx50(GJA8) but failing to do so with Cx40(GJA5).
PMID:15782139
Cx32 has a strong tumor-suppressive effect on a human metastatic renal cell carcinoma cell line.
Cx32-dependent inactivation of Src decreased the production of VEGF via the suppression of Stat3 activation
→ v-SRC*@Cytosol
→ c-SRC*|Y_pho|active@Cytosol
→ FYN@Cytosol
→ FAK1*|emp@Cytosol
→ PTK2B@Cytosol
→ ABL1@Cytosol