Protein WASP* map

Identifiers
HUGO:WAS
Wiskott-Aldrich syndrome
HUGO:WAS hgnc_id:HGNC:12731 HGNC:12731 ENTREZ:7454 UNIPROT:P42768
IMD2, THC, "thrombocytopenia 1 (X-linked)", "Wiskott-Aldrich syndrome (eczema-thrombocytopenia)"
HUGO:WAS HGNC:12731 ENTREZ:7454 UNIPROT:P42768

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / TCR_SIGNALING  map
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / MOTILITY  map
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CYTOSKELETON_POLARITY  map

References
PMID:11520460 PMID:14707117
PMID:21178402
Rac1 and Cdc42 activate ARP2/3 complex;
Rac1 and Cdc42 activate Wiskott-Aldrich Syndrome family of proteins including WASP, N-WASP and WAVE1/2.
PMID:11395419
Arp2/3 complex is intrinsically inactive, relying on nucleation promoting factors for activation. WASp/Scar family proteins are prominent cellular nucleation promoting factors. They bring together an actin monomer and Arp2/3 complex in solution or on the side of an existing actin filament to initiate a new filament that grows in the barbed end direction.
PMID:23212475
WAve and WASP proteins activate Arp2/3 complex
CDC42 induces actin cytoskeleton changes by activating WASP and N-WASP.
WASP and N-WASP binds to ARP2/3 and this lieads to actin cytoskeletal polymerization and filopodia formation.
PMID:8625410
PMID:16293614
PMID:10467124
PMID:10511705
 NATURAL_KILLER  map
 MACROPHAGE  map
CASCADE:CR3
CASCADE:Fc_gamma_RII
CASCADE:KIR2DL1
PMID:15001467, PMID:14707117
CD16 or ITGB2 (CD18) stimulation resulted in the induction of WASp tyrosine phosphorylation in NK cells,
probubly by Fyn. Fyn enhanced WASp-mediated Arp2/3 activation and was required for synapse formation in T cells.
PMID:12177428
NK cell cytotoxicity was deficient in WAS patients and WASp catalyzes actin polymerization.
It binds actin monomers as well as the actin-related protein (ARP) 2/3 complex to catalyze branching of filamentous actin (F-actin)
PMID:16606694
WIPF1 forms complex with WASP.
PMID:19741094
t Cdc42 is essential for the activation of WASP and N-WASP, leading to actin assembly and phagocytic cup formation by macrophages during Fc(gamma)R-mediated phagocytosis.
Cdc42 Is Required for Activation and Tyrosine Phosphorylation of WASP/N-WASP

Modifications:
In compartment: Cytosol
  1. WASP*@Cytosol map
  2. WASP*|​pho|​active@Cytosol map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. WASP*@INNATE_IMMUNE_CELL_Cytosol map
  2. WASP*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
In compartment: T_cell
  1. WASP*@T_cell map
  2. WASP*|​Tyr291_pho|​active@T_cell map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. WASP*|​pho:​WIPF1@INNATE_IMMUNE_CELL_Cytosol map
  2. TRIP10:​WASP*|​pho@INNATE_IMMUNE_CELL_Cytosol map
  3. WASP*|​pho:​WIPF1|​pho@INNATE_IMMUNE_CELL_Cytosol map
  4. ELC_MYOSIN_II*:​MYH9|​hm2:​RLC_MYOSIN_II*|​pho:​WASP*:​WIPF1|​pho@INNATE_IMMUNE_CELL_Cytosol map
  5. ACTR2:​ACTR3:​ARPC1*:​ARPC2:​ARPC3:​ARPC4:​ARPC5:​WASP*|​pho@INNATE_IMMUNE_CELL_Cytosol map
In compartment: T_cell
  1. WASP*|​Tyr291_pho:​WIPF1@T_cell map
  2. TRIP10:​WASP*|​Tyr291_pho@T_cell map
  3. WASP*|​Tyr291_pho:​WIPF1|​pho@T_cell map
  4. ELC_MYOSIN_II*:​MYH9|​hm2:​RLC_MYOSIN_II*|​pho:​WASP*:​WIPF1|​pho@T_cell map
  5. ACTR2:​ACTR3:​ARPC1*:​ARPC2:​ARPC3:​ARPC4:​ARPC5:​WASP*|​Tyr291_pho@T_cell map
Participates in reactions:
As Reactant or Product:
  1. ACTR2:​ACTR3:​ARPC1*:​ARPC2:​ARPC3:​ARPC4:​ARPC5@T_cell map + WASP*|​Tyr291_pho|​active@T_cell map → map ACTR2:​ACTR3:​ARPC1*:​ARPC2:​ARPC3:​ARPC4:​ARPC5:​WASP*|​Tyr291_pho@T_cell map
  2. WASP*|​Tyr291_pho|​active@T_cell map + TRIP10@T_cell map → map TRIP10:​WASP*|​Tyr291_pho@T_cell map
  3. WASP*|​Tyr291_pho:​WIPF1@T_cell map → map WASP*|​Tyr291_pho:​WIPF1|​pho@T_cell map
  4. WASP*|​Tyr291_pho|​active@T_cell map + WIPF1@T_cell map → map WASP*|​Tyr291_pho:​WIPF1@T_cell map
  5. WASP*@T_cell map → map WASP*|​Tyr291_pho|​active@T_cell map
  6. ELC_MYOSIN_II*:​MYH9|​hm2:​RLC_MYOSIN_II*|​pho@T_cell map + WASP*|​Tyr291_pho:​WIPF1|​pho@T_cell map → map ELC_MYOSIN_II*:​MYH9|​hm2:​RLC_MYOSIN_II*|​pho:​WASP*:​WIPF1|​pho@T_cell map
  7. WASP*|​Tyr291_pho|​active@T_cell map → map WASP*@T_cell map
  8. WASP*@Cytosol map → map WASP*|​pho|​active@Cytosol map
  9. WASP_NWASP*@Cytosol map → map WASP*@Cytosol map
  10. WASP*@INNATE_IMMUNE_CELL_Cytosol map → map WASP*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  11. ELC_MYOSIN_II*:​MYH9|​hm2:​RLC_MYOSIN_II*|​pho@INNATE_IMMUNE_CELL_Cytosol map + WASP*|​pho:​WIPF1|​pho@INNATE_IMMUNE_CELL_Cytosol map → map ELC_MYOSIN_II*:​MYH9|​hm2:​RLC_MYOSIN_II*|​pho:​WASP*:​WIPF1|​pho@INNATE_IMMUNE_CELL_Cytosol map
  12. ACTR2:​ACTR3:​ARPC1*:​ARPC2:​ARPC3:​ARPC4:​ARPC5@INNATE_IMMUNE_CELL_Cytosol map + WASP*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map → map ACTR2:​ACTR3:​ARPC1*:​ARPC2:​ARPC3:​ARPC4:​ARPC5:​WASP*|​pho@INNATE_IMMUNE_CELL_Cytosol map
  13. WASP*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map + TRIP10@INNATE_IMMUNE_CELL_Cytosol map → map TRIP10:​WASP*|​pho@INNATE_IMMUNE_CELL_Cytosol map
  14. WASP*|​pho:​WIPF1@INNATE_IMMUNE_CELL_Cytosol map → map WASP*|​pho:​WIPF1|​pho@INNATE_IMMUNE_CELL_Cytosol map
  15. WASP*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map + WIPF1@INNATE_IMMUNE_CELL_Cytosol map → map WASP*|​pho:​WIPF1@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. Actin cytoskeletal*@T_cell map → map Actin cytoskeletal*|​hm2@T_cell map
  2. PXN:​TUBGCP2:​TUBGCP3:​TUBGCP4:​TUBGCP5:​TUBGCP6:​Tubulin-_alpha_*:​Tubulin-_beta_*:​Tubulin-_gamma_*@T_cell map → map Centrosome polarization@T_cell map
  3. NFAT*|​pho@T_cell map → map NFAT*@T_cell map
  4. (ACTR2:​ACTR3:​ARPC1*:​ARPC2:​ARPC3:​ARPC4:​ARPC5)|​active@Cytosol map → map (ACTR2:​ACTR3:​ARPC1*:​ARPC2:​ARPC3:​ARPC4:​ARPC5)|​active@Cytosol map
  5. Actin cytoskeletal*@INNATE_IMMUNE_CELL_Cytosol map → map Actin cytoskeletal*|​hm2|​active@INNATE_IMMUNE_CELL_Cytosol map
  6. PXN:​TUBGCP2:​TUBGCP3:​TUBGCP4:​TUBGCP5:​TUBGCP6:​Tubulin-_alpha_*:​Tubulin-_beta_*:​Tubulin-_gamma_*@INNATE_IMMUNE_CELL_Cytosol map → map MTOC_polarization@INNATE_IMMUNE_CELL_Cytosol map