Identifiers
HUGO:ACTA2
Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / FIBROBLAST_ACTIVATION_MARKERS
Cancer Associated Fibroblasts / MOTILITY
References
CASCADE:TGFB
CASCADE:HGF
CASCADE:HH
PMID:12702545, PMID:8515656
Smad3 mediates transforming growth factor-beta-induced alpha-smooth muscle actin expression.
PMID:20129924
human corneal fibroblasts were transfected with small interfering RNA to alpha11, which decreased alpha-smooth muscle actin expression and myofibroblast differentiation.
PMID:23402812
Hepatocyte growth factor activates tumor stromal fibroblasts to promote tumorigenesis in gastric cancer.
HGF induces expression markers of activated fibroblasts such as FAP, CXCL12 (SDF1),aplpha-SMA
PMID:16179589
NAD(P)H oxidase 4 mediates transforming growth factor-beta1-induced differentiation of cardiac fibroblasts into myofibroblasts.
On stimulation with TGF-beta1, Nox4 mRNA is dramatically upregulated.
Depletion of Nox4 but not Nox5 inhibits baseline and TGF-beta1 stimulation of Smad 2/3 phosphorylation
Nox4 mediates TGFB1???induced SMalpha actin in human cardiac fibroblasts.