Reaction state_transition rc_re328 map

AKT*@Cytosol map → AKT*|​S473_pho|​T308_pho@Cytosol map

Reaction regulators:
Boolean_logic_gate_and
  1. and MAPKAP1:​RICTOR@Cytosol map
Catalysis
  1. PDPK1@Cytosol map
  2. MAPKAP1:​RICTOR@Cytosol map
Inhibition
  1. PHLDA3@Cytosol map
Unknown_catalysis
  1. WISP1@Cytosol map


References
PMID:19203586
PHLDA3 competes with the PH domain of Akt for binding of membrane lipids, thereby inhibiting Akt translocation to the cellular membrane and activation
PMID:15718470
TORC2 complex as AKT S473 kinase
PMID:22924465
PMID:22475393
ISP1 prevents apoptotic degeneration in primary neurons during oxidant stress through the activation of protein kinase B (Akt1)