Protein gp130* map

Identifiers
interleukin 6 signal transducer
HUGO:IL6ST hgnc_id:HGNC:6021 HGNC:6021 ENTREZ:3572 UNIPROT:P40189
HUGO:IL6ST

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / INFLAMMATORY_SIGNALING_PATHWAYS  map
 Innate Immunity  map  / IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS  map

References
PMID:11306493
IL4 signaling prevents CSF2RA(CD116) lost on DC surface in tumor microenviroment.
and blocks gp130 and CSF1R (CD115)surface expression.

Modifications:
In compartment: Cytosol
  1. gp130*@Cytosol map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. gp130*|​pho@INNATE_IMMUNE_CELL_Cytosol map
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. gp130*|​pho@INNATE_IMMUNE_CELL_Membrane map
Participates in complexes:
In compartment: Cytosol
  1. IL6R:​gp130*|​Y759_pho@Cytosol map
  2. LIFR:​gp130*|​Y759_pho@Cytosol map
  3. PLAUR:​gp130*|​Y759_pho@Cytosol map
  4. JAK1|​pho:​LIF:​LIFR:​gp130*|​Y759_pho@Cytosol map
  5. JAK1|​pho:​PLAU:​PLAUR:​gp130*|​Y759_pho@Cytosol map
  6. IL6R:​JAK1|​pho:​JAK2|​pho:​TYK2|​pho:​gp130*|​Y759_pho@Cytosol map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. IL6R:​SOCS3:​gp130*|​pho@INNATE_IMMUNE_CELL_Cytosol map
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. IL6R:​gp130*|​pho@INNATE_IMMUNE_CELL_Membrane map
  2. IL6:​IL6R:​gp130*|​pho@INNATE_IMMUNE_CELL_Membrane map
  3. IL6:​IL6R:​JAK1|​pho:​JAK2|​pho:​TYK2|​pho:​gp130*|​pho@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. gp130*@Cytosol map + IL6R@Cytosol map → map IL6R:​gp130*|​Y759_pho@Cytosol map
  2. rgp130@Cytosol map → map gp130*@Cytosol map
  3. IL6R:​gp130*|​Y759_pho@Cytosol map + JAK1|​pho@Cytosol map + TYK2|​pho@Cytosol map + JAK2|​pho@Cytosol map → map IL6R:​JAK1|​pho:​JAK2|​pho:​TYK2|​pho:​gp130*|​Y759_pho@Cytosol map
  4. gp130*@Cytosol map + LIFR@Cytosol map → map LIFR:​gp130*|​Y759_pho@Cytosol map
  5. JAK1|​pho@Cytosol map + LIFR:​gp130*|​Y759_pho@Cytosol map + LIF@default map → map JAK1|​pho:​LIF:​LIFR:​gp130*|​Y759_pho@Cytosol map
  6. gp130*@Cytosol map + PLAUR@Cytosol map → map PLAUR:​gp130*|​Y759_pho@Cytosol map
  7. PLAU@default map + PLAUR:​gp130*|​Y759_pho@Cytosol map + JAK1|​pho@Cytosol map → map JAK1|​pho:​PLAU:​PLAUR:​gp130*|​Y759_pho@Cytosol map
  8. IL6:​IL6R:​gp130*|​pho@INNATE_IMMUNE_CELL_Membrane map + JAK1|​pho@INNATE_IMMUNE_CELL_Cytosol map + TYK2|​pho@INNATE_IMMUNE_CELL_Cytosol map + JAK2|​pho@INNATE_IMMUNE_CELL_Cytosol map → map IL6:​IL6R:​JAK1|​pho:​JAK2|​pho:​TYK2|​pho:​gp130*|​pho@INNATE_IMMUNE_CELL_Membrane map
  9. SOCS3@INNATE_IMMUNE_CELL_Cytosol map + IL6R:​gp130*|​pho@INNATE_IMMUNE_CELL_Membrane map → map IL6R:​SOCS3:​gp130*|​pho@INNATE_IMMUNE_CELL_Cytosol map
  10. IL6R:​SOCS3:​gp130*|​pho@INNATE_IMMUNE_CELL_Cytosol map → map degraded
  11. IL6@default map + IL6R:​gp130*|​pho@INNATE_IMMUNE_CELL_Membrane map → map IL6:​IL6R:​gp130*|​pho@INNATE_IMMUNE_CELL_Membrane map
  12. gp130*|​pho@INNATE_IMMUNE_CELL_Membrane map + IL6R@INNATE_IMMUNE_CELL_Membrane map → map IL6R:​gp130*|​pho@INNATE_IMMUNE_CELL_Membrane map
  13. gp130*|​pho@INNATE_IMMUNE_CELL_Cytosol map → map gp130*|​pho@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. PTK2@Cytosol map → map PTK2|​pho@Cytosol map
  2. ITGB5@Cytosol map → map ITGB5|​ubi@Cytosol map
  3. STAT3@Cytosol map → map STAT3|​pho@Cytosol map
  4. TNF@INNATE_IMMUNE_CELL_Cytosol map → map TNF@default map
  5. JAK1@INNATE_IMMUNE_CELL_Cytosol map → map JAK1|​pho@INNATE_IMMUNE_CELL_Cytosol map
  6. TYK2@INNATE_IMMUNE_CELL_Cytosol map → map TYK2|​pho@INNATE_IMMUNE_CELL_Cytosol map
  7. JAK2@INNATE_IMMUNE_CELL_Cytosol map → map JAK2|​pho@INNATE_IMMUNE_CELL_Cytosol map
  8. STAT3@INNATE_IMMUNE_CELL_Cytosol map → map STAT3|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map