Protein LIF map

Identifiers
LIF, interleukin 6 family cytokine
HUGO:LIF hgnc_id:HGNC:6596 HGNC:6596 ENTREZ:3976 UNIPROT:P15018

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / INFLAMMATORY_SIGNALING_PATHWAYS  map
 Cancer Associated Fibroblasts  map  / CYTOKINES_CHEMOKINES_PRODUCTION  map

References
CASCADE:TGFB
CASCADE:IL1
CASCADE:TNF
CASCADE:LIF
PMID:24857661
LIF mediates TGF-??-dependent actomyosin contractility and extracellular matrix remodeling,
LIF as the major cytokine mediating STAT3 phosphorylation upon TGF-??1 stimulation.
TGF-??1 relies on a LIF/GP130-IL6ST/JAK1 signaling cascade to induce STAT3 activation.
LIF signaling mediates onset of a proinvasive microenvironment by proinvasive fibroblast activation and actomyosin contractility regulation independent of ??-SMA expression.

Modifications:
In compartment: Cytosol
  1. LIF@Cytosol map
In compartment: default
  1. LIF@default map
Participates in complexes:
In compartment: Cytosol
  1. JAK1|​pho:​LIF:​LIFR:​gp130*|​Y759_pho@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. LIF@Cytosol map → map Actomyosin_contractility@default map
  2. rLIF@Cytosol map → map LIF@Cytosol map
  3. LIF@Cytosol map → map LIF@default map
  4. JAK1|​pho@Cytosol map + LIFR:​gp130*|​Y759_pho@Cytosol map + LIF@default map → map JAK1|​pho:​LIF:​LIFR:​gp130*|​Y759_pho@Cytosol map
As Catalyser:
  1. STAT3@Cytosol map → map STAT3|​pho@Cytosol map
  2. gPDGFR*@Cytosol map → map rPDGFR*@Cytosol map