Protein IL6R map

Identifiers
interleukin 6 receptor
HUGO:IL6R hgnc_id:HGNC:6019 HGNC:6019 ENTREZ:3570 UNIPROT:P08887
HUGO:IL6R

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / INFLAMMATORY_SIGNALING_PATHWAYS  map
 Innate Immunity  map  / IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS  map

References
PMID:12754507, PMID:24418198
SOCS3 binds with high affinity to the phosphorylated Tyr759 (Y759)
Of gp130 to suppress IL-6 signaling.

Modifications:
In compartment: Cytosol
  1. IL6R@Cytosol map
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. IL6R@INNATE_IMMUNE_CELL_Membrane map
Participates in complexes:
In compartment: Cytosol
  1. IL6R:​gp130*|​Y759_pho@Cytosol map
  2. IL6R:​JAK1|​pho:​JAK2|​pho:​TYK2|​pho:​gp130*|​Y759_pho@Cytosol map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. IL6R:​SOCS3:​gp130*|​pho@INNATE_IMMUNE_CELL_Cytosol map
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. IL6R:​gp130*|​pho@INNATE_IMMUNE_CELL_Membrane map
  2. IL6:​IL6R:​gp130*|​pho@INNATE_IMMUNE_CELL_Membrane map
  3. IL6:​IL6R:​JAK1|​pho:​JAK2|​pho:​TYK2|​pho:​gp130*|​pho@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. gp130*@Cytosol map + IL6R@Cytosol map → map IL6R:​gp130*|​Y759_pho@Cytosol map
  2. rIL6R@Cytosol map → map IL6R@Cytosol map
  3. IL6R:​gp130*|​Y759_pho@Cytosol map + JAK1|​pho@Cytosol map + TYK2|​pho@Cytosol map + JAK2|​pho@Cytosol map → map IL6R:​JAK1|​pho:​JAK2|​pho:​TYK2|​pho:​gp130*|​Y759_pho@Cytosol map
  4. IL6:​IL6R:​gp130*|​pho@INNATE_IMMUNE_CELL_Membrane map + JAK1|​pho@INNATE_IMMUNE_CELL_Cytosol map + TYK2|​pho@INNATE_IMMUNE_CELL_Cytosol map + JAK2|​pho@INNATE_IMMUNE_CELL_Cytosol map → map IL6:​IL6R:​JAK1|​pho:​JAK2|​pho:​TYK2|​pho:​gp130*|​pho@INNATE_IMMUNE_CELL_Membrane map
  5. SOCS3@INNATE_IMMUNE_CELL_Cytosol map + IL6R:​gp130*|​pho@INNATE_IMMUNE_CELL_Membrane map → map IL6R:​SOCS3:​gp130*|​pho@INNATE_IMMUNE_CELL_Cytosol map
  6. IL6R:​SOCS3:​gp130*|​pho@INNATE_IMMUNE_CELL_Cytosol map → map degraded
  7. IL6@default map + IL6R:​gp130*|​pho@INNATE_IMMUNE_CELL_Membrane map → map IL6:​IL6R:​gp130*|​pho@INNATE_IMMUNE_CELL_Membrane map
  8. gp130*|​pho@INNATE_IMMUNE_CELL_Membrane map + IL6R@INNATE_IMMUNE_CELL_Membrane map → map IL6R:​gp130*|​pho@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. STAT3@Cytosol map → map STAT3|​pho@Cytosol map
  2. TNF@INNATE_IMMUNE_CELL_Cytosol map → map TNF@default map
  3. JAK1@INNATE_IMMUNE_CELL_Cytosol map → map JAK1|​pho@INNATE_IMMUNE_CELL_Cytosol map
  4. TYK2@INNATE_IMMUNE_CELL_Cytosol map → map TYK2|​pho@INNATE_IMMUNE_CELL_Cytosol map
  5. JAK2@INNATE_IMMUNE_CELL_Cytosol map → map JAK2|​pho@INNATE_IMMUNE_CELL_Cytosol map
  6. STAT3@INNATE_IMMUNE_CELL_Cytosol map → map STAT3|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map