Identifiers
plasminogen activator, urokinase
HUGO:PLAU hgnc_id:HGNC:9052 HGNC:9052 ENTREZ:5328 UNIPROT:P00749
HUGO:PLAU
Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / INFLAMMATORY_SIGNALING_PATHWAYS
Innate Immunity / TUMOR_GROWTH
References
CASCADE:PLAU
MODULE/CAF
PMID:27216177
FAP as a persistent activator of fibroblastic STAT3 through a uPAR-dependent FAK-Src-JAK2 signaling pathway.
PMID:22470492
Degradation of internalized ??v??5 integrin is controlled by uPAR bound uPA: effect on ??1 integrin activity and ??-SMA stress fiber assembly.
uPA (PLAU) signaling has a negative influence on myofibroblast differentiation;
MACROPHAGE
PMID:18633355
TAM express many pro-angiogenic and angiogenesis-modulating factors in vitro, such as VEGF, basic fibroblast growth factor (bFGF, also known as FGF2), tumour necrosis factor (TNF), interleukin 1 (IL1), chemokine (C-X-C motif) ligand 8 (CXCL8; also known as IL8), cyclooxygenase 2 (COX2, also known as PTGS2), plasminogen activator, urokinase (uPA, also known as PLAU), platelet derived growth factor beta.