RNA STAT3 map
HUGO:STAT3
MODULE:MACROPHAGE
MODULE:MDSC
MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS
PMID:21383238
Both miR-17-5p and miR-20a alleviate suppressive potential of myeloid-derived suppressor cells by modulating STAT3 expression.
miR-17-5p and miR-20a also reduced the transcriptional and protein levels of p47phox and gp91phox, two subunits of NADPH oxidase.
Modifications:
In compartment: Cytosol
  1. rSTAT3@Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. MIR17:​STAT3@Cytosol map
  2. MIR20A:​STAT3@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. gSTAT3@Cytosol map → map rSTAT3@Cytosol map
  2. rSTAT3@Cytosol map → map STAT3@Cytosol map
  3. rSTAT3@Cytosol map + arMIR20A@Cytosol map → map MIR20A:​STAT3@Cytosol map
  4. rSTAT3@Cytosol map + arMIR17@Cytosol map → map MIR17:​STAT3@Cytosol map
  5. MIR20A:​STAT3@Cytosol map → map degraded
  6. MIR17:​STAT3@Cytosol map → map degraded
As Catalyser: