RNA NCF1 map
HUGO:NCF1
MODULE:MDSC
MODULE:NO_ROS_PRODUCTION
PMID:19380816, PMID:21383238
The increased ROS production by MDSC is mediated by up-regulated activity of NADPH oxidase (NOX2).
STAT3 upregulates expression of NOX2 subunits, primarily p47(NCF1) and gp91(CYBB) in MDSC,
In the absence of NOX2 activity, MDSC lost the ability to suppress T cell responses and quickly differentiated into mature macrophages and dendritic cells.
Modifications:
In compartment: Cytosol
  1. rNCF1@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gNCF1@Cytosol map → map rNCF1@Cytosol map
    2. rNCF1@Cytosol map → map NCF1@Cytosol map
    As Catalyser: