RNA CYBB
HUGO:CYBB
MODULE:MDSC
MODULE:NO_ROS_PRODUCTION
PMID:19380816, PMID:21383238
The increased ROS production by MDSC is mediated by up-regulated activity of NADPH oxidase (NOX2).
STAT3 upregulates expression of NOX2 subunits, primarily p47(NCF1) and gp91(CYBB) in MDSC,
In the absence of NOX2 activity, MDSC lost the ability to suppress T cell responses and quickly differentiated into mature macrophages and dendritic cells.

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Modifications:
In compartment: Cytosol

1. rCYBB@Cytosol

Participates in complexes:

Participates in reactions:
As Reactant or Product:

1. gCYBB@Cytosol → rCYBB@Cytosol
2. rCYBB@Cytosol → CYBB@Cytosol

As Catalyser: