RNA IRF8
HUGO:IRF8
MODULE:MACROPHAGE
MODULE:MDSC
MODULE:CORE_SIGNALING_PATHWAYS
PMID:24091328
G-CSF downregulates IRF8 expression via STAT3 and GM-CSF via STAT5. IRF8 inhibition provides immunosuppressive functions of MDSC.

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Modifications:
In compartment: Cytosol

1. rIRF8@Cytosol

Participates in complexes:

Participates in reactions:
As Reactant or Product:

1. gIRF8@Cytosol → rIRF8@Cytosol
2. rIRF8@Cytosol → IRF8@Cytosol

As Catalyser: