Protein SHIP1* map

Identifiers
HUGO:INPP5D

Maps_Modules
MODULE:MACROPHAGE
MODULE:CORE_SIGNALING_PATHWAYS

References
PMID:11687500
SHIP catalyzes the conversion of PIP3 to PI(3,4)P2. It is a negative regulators of PI3K pathway.
PMID:21469115
SHIP inhibits PI3K signaling and prevents M2 polarisation downstream of IL4,
But IL4 signaling reduces SHIP protein levels and activity via PI3K correlating with M2 marker induction ( activation of arginase protein level and activity and inhibition of NO production).
PMID:20435894
SHIP inhibit MAPKp38 activation and prevent
MKNK1 phosphorylation by inhibiting the p38MAPK
pathway downstream of IL10.

SHIP1*@Cytosol

Identifiers

Maps_Modules

References

Modifications:
In compartment: Cytosol
  1. SHIP1*@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. SHIP1*@Cytosol map → map degraded
    2. rSHIP1*@Cytosol map → map SHIP1*@Cytosol map
    As Catalyser:
    1. PIP3*@Cytosol map → map PIP2*@Cytosol map
    2. p38*@Cytosol map → map p38*|​pho|​active@Cytosol map