Identifiers
NAME:CD247:CD3*:ZAP70:alpha_/beta_TCR*
References
PMID:21059766 PMID:23886063??
Identifiers
NAME:CD247:CD3*:ZAP70:alpha_/beta_TCR*
References
PMID:21059766 PMID:23886063??
Identifiers
NAME:CD247:CD3*:ZAP70:alpha_/beta_TCR*
References
PMID:21059766 PMID:23886063??
ad_re383( Adaptive Immune Response ):
PMID:11875494
IL10-induced p38 phosphorylation.
PMID:20435894
SHIP inhibit MAPKp38 activation and prevent
MKNK1 phosphorylation by inhibiting the p38MAPK
pathway downstream of IL10.
PMID:10925299
IL13 induces p38 MAPK phosphorilation and activation, p38 MAPK participates in arginase activation??downstream of IL13.
PMID:23508573
HMGB1 induces activation (phosphorylation) of p38 via TLR4.
PMID:12811837, PMID:16713974
TLR signaling can induces STAT1 phosphorylation via p38 and potentiate IFNG signaling.
PMID:16713974
TLR2 activates (induces phosphorylation of) ERKs, JNKs, and p38 rapidly and transiently in control macrophages.
This activation is inhibited by IFNG signaling.
PMID:11438547, PMID:24378531
Both TNFR1 and TNFR2 signaling pathways are needed for activation of p38 MAPK.
→ CD247|pho:CD3*|pho:ZAP70|pho:alpha_/beta_TCR*@cSMAC
+ ZAP70@cSMAC → CD247|pho:CD3*|pho:ZAP70:alpha_/beta_TCR*@cSMAC
→ CD247|pho|ubi:CD3*|pho:ZAP70:alpha_/beta_TCR*@cSMAC
→ degraded
+ PXN|pho@T_cell → PXN:TUBGCP2:TUBGCP3:TUBGCP4:TUBGCP5:TUBGCP6:Tubulin-_alpha_*:Tubulin-_beta_*:Tubulin-_gamma_*@T_cell
→ p38*|Tyr323_pho@T_cell
→ CD6|pho@cSMAC
+ PLCG1@T_cell + GRB2@T_cell + GRAP2@T_cell + GRAP@T_cell → GRAP:GRAP2:GRB2:LAT|pho:PLCG1@T_cell
→ GAB2|pho@T_cell
→ LCP2|pho@T_cell
→ VAV2|pho@T_cell
→ VAV3|pho@T_cell
→ rCK2*@T_cell