Identifiers
HUGO:ZAP70
zeta-chain (TCR) associated protein kinase 70kDa
SRK, "zeta-chain (TCR) associated protein kinase (70 kD)"
HUGO:ZAP70 HGNC:12858 ENTREZ:7535 UNIPROT:P43403

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response   / SMAC 
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence   / EMT_REGULATORS 
 EMT Senescence   / CYTOSKELETON_POLARITY 

References
PMID:23620508 PMID:7600293 PMID:8642247 PMID:15735648 PMID:12415267 PMID:17371980
CASCADE:KIR2DS2
CASCADE:NKP44
CASCADE:NKP46
CASCADE:NKP30
 NATURAL_KILLER 
CASCADE:INTEGRIN_A4B1
CASCADE:INTEGRIN_A5B1
CASCADE:Fc_gamma_RIII
PMID:20814939, PMID:12731048
Phosphorylation of the ITAM sequence in the associated partner chains induces binding and phosphorylation of tyrosine kinases Syk and ZAP70 to the ITAM downstream of NKp30 or NKp46 or NKp44

1. ZAP70@cSMAC

1. CD247|​pho:​CD3*|​pho:​ZAP70:​alpha_/beta_TCR*@cSMAC
2. CD247|​pho:​CD3*|​pho:​ZAP70|​pho:​alpha_/beta_TCR*@cSMAC
3. CD247|​pho|​ubi:​CD3*|​pho:​ZAP70:​alpha_/beta_TCR*@cSMAC

1. CD247|​pho:​CD3*|​pho:​ZAP70:​alpha_/beta_TCR*@cSMAC → CD247|​pho:​CD3*|​pho:​ZAP70|​pho:​alpha_/beta_TCR*@cSMAC
2. CD247|​pho:​CD3*|​pho:​alpha_/beta_TCR*@cSMAC + ZAP70@cSMAC → CD247|​pho:​CD3*|​pho:​ZAP70:​alpha_/beta_TCR*@cSMAC
3. CD247|​pho:​CD3*|​pho:​ZAP70:​alpha_/beta_TCR*@cSMAC → CD247|​pho|​ubi:​CD3*|​pho:​ZAP70:​alpha_/beta_TCR*@cSMAC
4. CD247|​pho|​ubi:​CD3*|​pho:​ZAP70:​alpha_/beta_TCR*@cSMAC → degraded

1. TUBGCP2:​TUBGCP3:​TUBGCP4:​TUBGCP5:​TUBGCP6:​Tubulin-_alpha_*:​Tubulin-_beta_*:​Tubulin-_gamma_*@T_cell + PXN|​pho@T_cell → PXN:​TUBGCP2:​TUBGCP3:​TUBGCP4:​TUBGCP5:​TUBGCP6:​Tubulin-_alpha_*:​Tubulin-_beta_*:​Tubulin-_gamma_*@T_cell
2. p38*@T_cell → p38*|​Tyr323_pho@T_cell
3. CD6@cSMAC → CD6|​pho@cSMAC
4. LAT@T_cell + PLCG1@T_cell + GRB2@T_cell + GRAP2@T_cell + GRAP@T_cell → GRAP:​GRAP2:​GRB2:​LAT|​pho:​PLCG1@T_cell
5. GAB2@T_cell → GAB2|​pho@T_cell
6. LCP2@T_cell → LCP2|​pho@T_cell
7. VAV2@T_cell → VAV2|​pho@T_cell
8. VAV3@T_cell → VAV3|​pho@T_cell
9. gCK2@T_cell → rCK2*@T_cell