Identifiers
HUGO:LAT
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Adaptive Immune Response / TCR_SIGNALING
Innate Immunity / IMMUNOSTIMULATORY_CORE_PATHWAYS
References
PMID:23620508 PMID:10811803 PMID:25137453 PMID:16102570 PMID:12640133 PMID:14764585 PMID:19494291
NATURAL_KILLER
MAST_CELL
CASCADE:2B4
CASCADE:Fc_gamma_RIII
PMID:10072481, PMID:16329184, PMID:11169415
LAT participate in NK-cell cytotoxicity against tumor cells downstream of CD16 and 2B4 signaling.
LAT is phosphorylated downstream of 2B4 and CD16
PMID:9489702, PMID:10072481, PMID:7523143
LAT is a substrate for ZAP-70, Syk protein tyrosine kinases in T cells and probably in NK cells.
PMID:11169415, PMID:10072481, PMID:8649391
Tyrosine phosphorylation of LAT led to the recruitment of intracytoplasmic signaling molecules including phospholipase Cgamma and Grb2
and activation of phosphatidylinositol pathway.
PMID:8976179
PTP-1C (SHP-1) binds to and dephosphorylates pp36 (LAT) and disrupted the ability of pp36 (LAT) to associate with Grb2 downstream of KIR3DL1.
PMID:10781611
The adapter protein LAT enhances fcgamma receptor-mediated signal transduction in myeloid cells.
Co-immunoprecipitation experiments revealed a constitutive association of p36 LAT with both FcgammaRI and FcgammaRIIa immunoprecipitates, and an activation-induced association of LAT with PLCgamma1, Grb2, and the p85 subunit of phosphatidylinositol 3-kinase.
bone marrow-derived macrophages from LAT-deficient mice displayed reduced phagocytic efficiency in comparison to the macrophages from wild-type mice.
PMID:19909365
LAT is adaptor protein f Fc epsilon RI signaling in mast cells