Protein GAB2 map

Identifiers
HUGO:GAB2

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / INHIBITING_CHECKPOINTS  map
 Adaptive Immune Response  map  / TCR_SIGNALING  map
 Innate Immunity  map  / IMMUNOSTIMULATORY_CORE_PATHWAYS  map

References
PMID:11572860 PMID:12640133
 MAST_CELL  map
 NATURAL_KILLER  map
PMID:16212621, PMID:10982827
Phosphorylation of Gab2 was enhanced by both IL-2 and IL-15 in T cells.
IL-2- and IL-15-induced Gab2-PI3K association and downstream AKT activation in T cells and B cells.
PMID:10849428
IL-2 but not IL-4, IL-12, or IFN-??/??, was able to induce the phosphorylation of Gab2 in NK cells
and induces its association with PI3K (p85).
JAK3 probably plays a pivotal role for in IL-2-dependent Gab2 phosphorylation.
PMID:19909365
GAB2 lthough it has been long recognized that PI3K signaling is important for the regulation of
Fc??RI-mediated activation of MCs (161???163), the molecular link between Fc??RI and
activation of PI3K

Modifications:
In compartment: T_cell
  1. GAB2@T_cell map
  2. GAB2|​pho@T_cell map
Participates in complexes:
In compartment: T_cell
  1. GAB2|​pho:​PTPN11@T_cell map
Participates in reactions:
As Reactant or Product:
  1. GAB2@T_cell map → map GAB2|​pho@T_cell map
  2. PTPN11@T_cell map + GAB2|​pho@T_cell map → map GAB2|​pho:​PTPN11@T_cell map
As Catalyser:
  1. CD247|​pho:​CD3*|​pho:​alpha_/beta_TCR*@cSMAC map → map CD247:​CD3*:​alpha_/beta_TCR*@cSMAC map
  2. LCP2@T_cell map → map LCP2|​pho@T_cell map