Protein CD247 map

Identifiers
HUGO:CD247

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / SMAC  map
 Innate Immunity  map  / FC_RECEPTORS  map

References
PMID:9738502 PMID:21059766 PMID:11353765
 NATURAL_KILLER  map
 MACROPHAGE  map
CASCADE:NKP46
CASCADE:NKP30
CASCADE:NKG2A
CASCADE:Fc_gamma_RIII
PMID:10562324, PMID:23414611
To initiate signal transduction, NKp30 associates with immunoreceptor tyrosine based activation motif (ITAM)-containing adaptor proteins, such as disulfide-linked homodimers of CD247 (CD3zeta).
PMID:23414611, PMID:23414611, PMID:9625766
Nkp46 (NCR1) is the most specific marker of NK cells reported so far. For signalling, NKp46 associates with CD247 (CD3??) and also with the ??-chain of Fc??RI. Nkp46 signaling is activated by unknown ligands expressed on tumor cells.
PMID:8478617
Fc gamma RIII crosslinking results in activation of the src-related kinase p56lck in NK cells.
CD3 zeta is phosphorilated by LCK

Modifications:
Participates in complexes:
In compartment: cSMAC
  1. CD247:​CD3*:​alpha_/beta_TCR*@cSMAC map
  2. CD247|​pho:​CD3*|​pho:​alpha_/beta_TCR*@cSMAC map
  3. CD247|​pho:​CD3*|​pho:​ZAP70:​alpha_/beta_TCR*@cSMAC map
  4. CD247|​pho:​CD3*|​pho:​ZAP70|​pho:​alpha_/beta_TCR*@cSMAC map
  5. CD247|​pho|​ubi:​CD3*|​pho:​ZAP70:​alpha_/beta_TCR*@cSMAC map
Participates in reactions:
As Reactant or Product:
  1. CD247:​CD3*:​alpha_/beta_TCR*@cSMAC map → map CD247|​pho:​CD3*|​pho:​alpha_/beta_TCR*@cSMAC map + PTPRC@dSMAC map
  2. CD247|​pho:​CD3*|​pho:​alpha_/beta_TCR*@cSMAC map → map CD247:​CD3*:​alpha_/beta_TCR*@cSMAC map
  3. CD247|​pho:​CD3*|​pho:​ZAP70:​alpha_/beta_TCR*@cSMAC map → map CD247|​pho:​CD3*|​pho:​ZAP70|​pho:​alpha_/beta_TCR*@cSMAC map
  4. CD247|​pho:​CD3*|​pho:​alpha_/beta_TCR*@cSMAC map + ZAP70@cSMAC map → map CD247|​pho:​CD3*|​pho:​ZAP70:​alpha_/beta_TCR*@cSMAC map
  5. CD247|​pho:​CD3*|​pho:​ZAP70:​alpha_/beta_TCR*@cSMAC map → map CD247|​pho|​ubi:​CD3*|​pho:​ZAP70:​alpha_/beta_TCR*@cSMAC map
  6. CD247|​pho|​ubi:​CD3*|​pho:​ZAP70:​alpha_/beta_TCR*@cSMAC map → map degraded
As Catalyser:
  1. TUBGCP2:​TUBGCP3:​TUBGCP4:​TUBGCP5:​TUBGCP6:​Tubulin-_alpha_*:​Tubulin-_beta_*:​Tubulin-_gamma_*@T_cell map + PXN|​pho@T_cell map → map PXN:​TUBGCP2:​TUBGCP3:​TUBGCP4:​TUBGCP5:​TUBGCP6:​Tubulin-_alpha_*:​Tubulin-_beta_*:​Tubulin-_gamma_*@T_cell map
  2. p38*@T_cell map → map p38*|​Tyr323_pho@T_cell map
  3. CD6@cSMAC map → map CD6|​pho@cSMAC map
  4. LAT@T_cell map + PLCG1@T_cell map + GRB2@T_cell map + GRAP2@T_cell map + GRAP@T_cell map → map GRAP:​GRAP2:​GRB2:​LAT|​pho:​PLCG1@T_cell map
  5. GAB2@T_cell map → map GAB2|​pho@T_cell map
  6. LCP2@T_cell map → map LCP2|​pho@T_cell map
  7. VAV2@T_cell map → map VAV2|​pho@T_cell map
  8. VAV3@T_cell map → map VAV3|​pho@T_cell map
  9. gCK2@T_cell map → map rCK2*@T_cell map