Protein VAV2 map

Identifiers
HUGO:VAV2
vav 2 guanine nucleotide exchange factor
HUGO:VAV2, HGNC:12658, ENTREZ:7410, GENECARDS:GC09M136627, UNIPROT:P52735

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / TCR_SIGNALING  map
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CYTOSKELETON_POLARITY  map
 Innate Immunity  map  / IMMUNOSTIMULATORY_CORE_PATHWAYS  map

References
PMID:15886116 PMID:14623913 PMID:10934226 PMID:11262396
PMID:9822605
Phosphorylated Vav-2 was found to be active on RhoA, RhoB and the more distantly related RhoG protein
VAV1,2 are GEFs for Rac1.
PMID:11080163
VAV2 is recruited by the CD19 co-receptor of the B cells and participates in the B cell receptor signaling.
 NATURAL_KILLER  map
PMID:15365099
VAV2 and VAV3 participate in signal transduction downstream of ITAM-containing adapters (CD3zeta, FcR gamma, DAP12)
PMID:??12094222??
VAV proteins activate RAC1 via induction of GDP/GTP exchange.

VAV2|​pho@T_cell

References
ad_re362( Adaptive Immune Response  map ):
PMID:16713974
GSK3B inhitits activation (DNA binding) of AP-1 factors.
JNK is a classical activator of AP1 transcription factors.
Inhibition of JNK downregulates IL10 expression. Probably via
AP1.

Modifications:
In compartment: T_cell
  1. VAV2@T_cell map
  2. VAV2|​pho@T_cell map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. VAV2@T_cell map → map VAV2|​pho@T_cell map
    As Catalyser:
    1. Ca2+:​Calmodulin*@T_cell map + CNA*:​CNB*@T_cell map → map CNA*:​CNB*:​Ca2+:​Calmodulin*@T_cell map
    2. NFAT*|​pho@T_cell map → map NFAT*@T_cell map
    3. AP1*@T_cell map → map AP1*|​pho|​active@T_cell map
    4. GDP:​HRAS@T_cell map + GTP@T_cell map → map (GTP:​HRAS)|​active@T_cell map + GDP@T_cell map