Protein TMBIM3
Identifiers
glutamate ionotropic receptor NMDA type subunit associated protein 1
HUGO:GRINA hgnc_id:HGNC:4589 HGNC:4589 ENTREZ:2907 UNIPROT:Q7Z429
Maps_Modules
HMC:RESISTING_CELL_DEATH
Regulated Cell Death
/ ER_STRESS
References
PMID:23850759
PMID:23430059
Binding of Bax and Bak to IRE1 is negatively regulated by Bax Inhibitor 1 (BI-1), a transmembrane protein localized to the ER and nuclear envelope
Modifications:
In compartment: Endopasmic Reticulum
- TMBIM3@Endopasmic Reticulum
- TMBIM3|ubi@Endopasmic Reticulum
Participates in complexes:
In compartment: Endopasmic Reticulum
- BAX:TMBIM3@Endopasmic Reticulum
- BAK1:TMBIM3@Endopasmic Reticulum
Participates in reactions:
As Reactant or Product:- TMBIM3@Endopasmic Reticulum
→
release of ER Ca2+@Cytosol
- TMBIM3@Endopasmic Reticulum
+ BAK1@Endopasmic Reticulum
→
BAK1:TMBIM3@Endopasmic Reticulum
- BAX@Endopasmic Reticulum
+ TMBIM3@Endopasmic Reticulum
→
BAX:TMBIM3@Endopasmic Reticulum
- TMBIM3@Endopasmic Reticulum
→
TMBIM3|ubi@Endopasmic Reticulum
- TMBIM3|ubi@Endopasmic Reticulum
→
degraded
As Catalyser: