Protein FGF1 map

Identifiers
fibroblast growth factor 1
HUGO:FGF1 hgnc_id:HGNC:3665 HGNC:3665 ENTREZ:2246 UNIPROT:P05230
fibroblast growth factor 1 (acidic)
HUGO:FGF1, HGNC:3665, ENTREZ:2246, GENECARDS:GC05M141953, UNIPROT:P05230

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / ECM  map

References
PMID:9242465
IL1B, FGF2, FGF1, FGF4, PDGF induce HGF expression and production in fibroblasts
PMID:26183471
CAFs secrete more FGF-1/-3 than normal fibroblasts
PMID:14517404
Fibroblast growth factor FGF1, a prototypic member of the FGF family, has the ability to stimulate angiogenesis in an in vivo model of angiogenesis.
Eggs received secreted FGF1 showed a significant increase in vascularization when compared to eggs received vector alone plasmids.
PMID:16272825
This FGF1-mediated angiogenesis involves in the PI3K/AKT pathway.
Blocked PI3K pathway via LY294002 in FGF1-transfected CAMs (chicken chorio- allantoic membrane) signifi cantly inhibited angiogenesis
PMID:16682805
Both activity and mRNA expression levels of the Ets1 molecule were increased in response to FGF1 overexpression
Ets-1 activation is a requisite for FGF1-mediated angiogenesis in vivo.

FGF1@Extracellular space

References
em_emtc_emtc_re372( EMT Senescence  map ):
PMID:14517404
Fibroblast growth factor FGF1, a prototypic member of the FGF family, has the ability to stimulate angiogenesis in an in vivo model of angiogenesis.
Eggs received secreted FGF1 showed a significant increase in vascularization when compared to eggs received vector alone plasmids.
PMID:16272825
This FGF1-mediated angiogenesis involves in the PI3K/AKT pathway.
Blocked PI3K pathway via LY294002 in FGF1-transfected CAMs (chicken chorio- allantoic membrane) signifi cantly inhibited angiogenesis
PMID:16682805
Both activity and mRNA expression levels of the Ets1 molecule were increased in response to FGF1 overexpression
Ets-1 activation is a requisite for FGF1-mediated angiogenesis in vivo.
em_emtc_emtc_re354( EMT Senescence  map ):
PMID:21081489
miR-200b interacts with the ETS1 to exert translational repression
It is not clear yet whether miR-200b targets Ets1 for degradation, or it only inhibits translation of Ets1.

Modifications:
In compartment: Cytosol
  1. FGF1@Cytosol map
In compartment: Extracellular space
  1. FGF1@Extracellular space map
In compartment: default
  1. FGF1@default map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. FGF1@Cytosol map → map FGF1@default map
    2. FGFR1-ligands*@Extracellular space map → map FGF1@Extracellular space map
    3. FGFR3-ligands*@Extracellular space map → map FGF1@Extracellular space map
    4. FGFR4-ligands*@Extracellular space map → map FGF1@Extracellular space map
    5. rFGF1@Nucleus map → map FGF1@Cytosol map
    6. FGF1@Cytosol map → map FGF1@Extracellular space map
    As Catalyser:
    1. gHGF@Cytosol map → map rHGF@Cytosol map
    2. FGFR1@Cytosol map → map FGFR1@Cytosol map
    3. rETS1@Nucleus map → map ETS1@Cytosol map