→ ETS1@Cytosol References
PMID:21081489
miR-200b interacts with the ETS1 to exert translational repression
It is not clear yet whether miR-200b targets Ets1 for degradation, or it only inhibits translation of Ets1.
PMID:14517404
Fibroblast growth factor FGF1, a prototypic member of the FGF family, has the ability to stimulate angiogenesis in an in vivo model of angiogenesis.
Eggs received secreted FGF1 showed a significant increase in vascularization when compared to eggs received vector alone plasmids.
PMID:16272825
This FGF1-mediated angiogenesis involves in the PI3K/AKT pathway.
Blocked PI3K pathway via LY294002 in FGF1-transfected CAMs (chicken chorio- allantoic membrane) significantly inhibited angiogenesis
PMID:16682805
Both activity and mRNA expression levels of the Ets1 molecule were increased in response to FGF1 overexpression
Ets-1 activation is a requisite for FGF1-mediated angiogenesis in vivo.