RNA ETS1 map

Identifiers
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
HUGO:ETS1, HGNC:3488, ENTREZ:2113, GENECARDS:GC11M128328
HUGO:ETS1

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / MIRNA_TF_IMMUNOSTIMULATORY  map

References
PMID:16391805
Ets-1 is a transcription factor
Ets-1 involves in inducing MMP2 expression by EMT in human squamous carcinoma cells
PMID:21081489
miR-200b targets Ets-1 and is down-regulated by Hypoxia to induce Angiogenic response of Endothelial cells
 NATURAL_KILLER  map
CASCADE:IL15
CASCADE:IL2
PMID:15563472
Interleukins 15 and IL2 regulate Ets1 expression via ERK1/2 and MNK1 in human natural killer cells.

rETS1@Nucleus

References
em_emtc_emtc_re353( EMT Senescence  map ):
PMID:9157999
VEGF increased the level of ETS1 mRNA in human umbifical vein endothelial cells and lung microvascular endothelial cells over 5-fold.
Protein levels were shown to increase concordantly.
PMID:15111329
VEGF induces Ets-1 expression in bovine retinal endothelial cells and its expression is PKC/ERK pathway-dependent.
Ets-1 up-regulation is involved in the development of retinal neovascularization, and inhibition of Ets-1 may be beneficial in the treatment of ischemic ocular diseases
PMID:12490555
Snail is able to induce the expression of Slug and all other neural crest markers (Zic5, FoxD3, Twist and Ets1)
PMID:16716598
PMID:11708773
Endothelin1 is target gene of HIF1
PMID:21041997
In cells induced to undergo EMT, TGFB also activates the expresion of ZEB1 and ZEB2 through upregulation of ETS1 expression, which then may cooperate with the bHLH transcription factor E47 (TCF3)
PMID:17615296
TGFB induces ETS1 transcriptional expression.
TGFB represses ID2 and ID3 transcriptional expression (PMID:15121845 and PMID:15181457)
ID2 may regulate the function of Ets1 to modulate the transcription of ZEB1 and ZEB2 without alteration of the transcription of Ets1.
Ets1 may act as an inducer of ZEB1 in collaboration with E47 (TCF3)
em_emtc_emtc_re354( EMT Senescence  map ):
PMID:21081489
miR-200b interacts with the ETS1 to exert translational repression
It is not clear yet whether miR-200b targets Ets1 for degradation, or it only inhibits translation of Ets1.
PMID:14517404
Fibroblast growth factor FGF1, a prototypic member of the FGF family, has the ability to stimulate angiogenesis in an in vivo model of angiogenesis.
Eggs received secreted FGF1 showed a significant increase in vascularization when compared to eggs received vector alone plasmids.
PMID:16272825
This FGF1-mediated angiogenesis involves in the PI3K/AKT pathway.
Blocked PI3K pathway via LY294002 in FGF1-transfected CAMs (chicken chorio- allantoic membrane) significantly inhibited angiogenesis
PMID:16682805
Both activity and mRNA expression levels of the Ets1 molecule were increased in response to FGF1 overexpression
Ets-1 activation is a requisite for FGF1-mediated angiogenesis in vivo.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. rETS1@INNATE_IMMUNE_CELL_Cytosol map
In compartment: Nucleus
  1. rETS1@Nucleus map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. rETS1_WASF3_WAVE3*@Nucleus map → map rETS1@Nucleus map
    2. gETS1@Nucleus map → map rETS1@Nucleus map
    3. rETS1@Nucleus map → map ETS1@Cytosol map
    4. gETS1@INNATE_IMMUNE_CELL_Cytosol map → map rETS1@INNATE_IMMUNE_CELL_Cytosol map
    5. rETS1@INNATE_IMMUNE_CELL_Cytosol map → map ETS1@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser: