Identifiers
pyruvate dehydrogenase (lipoamide) alpha 1
HUGO:PDHA1 HGNC:8806 ENTREZ:5160 UNIPROT:P08559
pyruvate dehydrogenase (lipoamide) alpha 2
HUGO:PDHA2 HGNC:8807 ENTREZ:5161 UNIPROT:P29803

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death   / MITOCHONDRIAL_METABOLISM 
 Regulated Cell Death   / OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE 
 RECON2 

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death   / MITOCHONDRIAL_METABOLISM 
 Regulated Cell Death   / OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE 

References
rc_re1459:( Regulated Cell Death  ) reactionType:is.a

1. PDHA*@Mitochondrial Matrix

1. PDHA*|​hm2:​PDHB|​hm2@Mitochondrial Matrix
2. DLAT|​lipoylated:​DLD:​FAD:​PDHA*:​thiamine diphosphate@Mitochondrial Matrix
3. DLAT|​lipoylated:​DLD:​FAD:​PDHA*|​pho:​thiamine diphosphate@Mitochondrial Matrix

1. PDHA2@Mitochondrial Matrix → PDHA*@Mitochondrial Matrix
2. PDHA1@Mitochondrial Matrix → PDHA*@Mitochondrial Matrix
3. PDHA*@Mitochondrial Matrix + PDHB@Mitochondrial Matrix → PDHA*|​hm2:​PDHB|​hm2@Mitochondrial Matrix
4. DLAT|​lipoylated:​DLD:​FAD:​PDHA*|​pho:​thiamine diphosphate@Mitochondrial Matrix → DLAT|​lipoylated:​DLD:​FAD:​PDHA*:​thiamine diphosphate@Mitochondrial Matrix
5. DLAT|​lipoylated:​DLD:​FAD:​PDHA*:​thiamine diphosphate@Mitochondrial Matrix + ATP@Mitochondrial Matrix → DLAT|​lipoylated:​DLD:​FAD:​PDHA*|​pho:​thiamine diphosphate@Mitochondrial Matrix + ADP@Mitochondrial Matrix

1. pyruvate@Mitochondrial Matrix + coenzyme A@Mitochondrial Matrix + NAD_super_+_endsuper_@Mitochondrial Matrix → acetyl-CoA@Mitochondrial Matrix + NADH@Mitochondrial Matrix + CO_sub_2_endsub_@Mitochondrial Matrix + H+@Mitochondrial Matrix