Protein POLDIP2 map

Identifiers
HUGO:POLDIP2

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / METABOLIC  map

References
PMID:19644055
Poldip2 co-localizes with p22phox at sites of Nox4 in SMCs and, when present, increases Nox4 activity by three-fold. In addition, Nox4-Poldip2-derived ROS activate RhoA to strengthen focal adhesions and increase stress fiber formation.

Modifications:
In compartment: Cytosol
  1. POLDIP2@Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. CYBA:​NOX4:​POLDIP2:​heme@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. CYBA@Cytosol map + NOX4@Cytosol map + heme@Cytosol map + POLDIP2@Cytosol map → map CYBA:​NOX4:​POLDIP2:​heme@Cytosol map
As Catalyser:
  1. O_sub_2_endsub_@Cytosol map → map O_sub_2_endsub__super_-_endsuper_@Cytosol map