Protein NOX4 map

Identifiers
HUGO:NOX4
NADPH oxidase 4
HUGO:NOX4 HGNC:7891 ENTREZ:50507 UNIPROT:Q9NPH5

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / METABOLIC  map
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / NECROPTOSIS  map

References
CASCADE:TGFB
PMID:15927447; PMID:19995913
Nox4, in contrast to other Nox proteins, produces large amounts of hydrogen peroxide constitutively. Known cytosolic oxidase proteins or the GTPase Rac are not required for this activity. Nox4 associates with the protein p22phox on internal membranes, where ROS generation occurs. Knockdown and gene transfection studies confirmed that Nox4 requires p22phox for ROS generation
PMID:16179589
NAD(P)H oxidase 4 mediates transforming growth factor-beta1-induced differentiation of cardiac fibroblasts into myofibroblasts.
On stimulation with TGF-beta1, Nox4 mRNA is dramatically upregulated.
Depletion of Nox4 but not Nox5 inhibits baseline and TGF-beta1 stimulation of Smad 2/3 phosphorylation
Nox4 mediates TGFB1???induced SMalpha actin in human cardiac fibroblasts.
PMID:21273445
ROS signaling by NOX4 drives fibroblast-to-myofibroblast transdifferentiation in the diseased prostatic stroma downstream of TGFB

Modifications:
In compartment: Cytosol
  1. NOX4@Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. CYBA:​NOX4:​POLDIP2:​heme@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. CYBA@Cytosol map + NOX4@Cytosol map + heme@Cytosol map + POLDIP2@Cytosol map → map CYBA:​NOX4:​POLDIP2:​heme@Cytosol map
  2. rNOX4@Cytosol map → map NOX4@Cytosol map
  3. NOX4@Cytosol map → map NOX*@Cytosol map
As Catalyser:
  1. O_sub_2_endsub_@Cytosol map → map O_sub_2_endsub__super_-_endsuper_@Cytosol map