Complex CYBA:NOX4:POLDIP2:heme map
Complex composition:

  1. POLDIP2 map
  2. NOX4 map
  3. CYBA map
  4. heme map

CYBA:​NOX4:​POLDIP2:​heme@Cytosol

Identifiers
NAME:CYBA:NOX4:POLDIP2:heme

References
CASCADE:TGFB
PMID:19995913
PMID:16179589
NAD(P)H oxidase 4 mediates transforming growth factor-beta1-induced differentiation of cardiac fibroblasts into myofibroblasts.
On stimulation with TGF-beta1, Nox4 mRNA is dramatically upregulated.
Depletion of Nox4 but not Nox5 inhibits baseline and TGF-beta1 stimulation of Smad 2/3 phosphorylation
Nox4 mediates TGFB1???induced SMalpha actin in human cardiac fibroblasts.
PMID:21273445
ROS signaling by NOX4 drives fibroblast-to-myofibroblast transdifferentiation in the diseased prostatic stroma downstream of TGFB
ca_re649( Cancer Associated Fibroblasts  map ):
PMID:19732719
Inhibition of TGF-?? signaling??in vivo??increases CD11b+??cell cytotoxicity via an oxygen radical-dependent mechanism (superoxide?? and H2O2 production) in neutrophils

Modifications:
Participates in complexes:
In compartment: Cytosol
  1. CYBA:​NOX4:​POLDIP2:​heme@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. CYBA@Cytosol map + NOX4@Cytosol map + heme@Cytosol map + POLDIP2@Cytosol map → map CYBA:​NOX4:​POLDIP2:​heme@Cytosol map
As Catalyser:
  1. O_sub_2_endsub_@Cytosol map → map O_sub_2_endsub__super_-_endsuper_@Cytosol map