Phenotype TUMOR_INVASION map
TUMOR_INVASION@default

References
PMID:19937793
Microarray and real-time PCR analysis identified marked upregulation of the chemokine (C-C motif) ligand 7 (CCL7) in cocultured CAF. ELISA showed an elevated level of CCL7 secretion from CAF stimulated by coculture with OSCC cells. CCL7 promoted the invasion and migration of OSCC cells, and the invasiveness was inhibited by treatment with CCL7 neutralizing antibody. OSCC cells were shown to express CCR1, CCR2 and CCR3, receptors for CCL7, by RT-PCR. In addition, treatment with anti-CCR1 or anti-CCR3 antibody inhibited CCL7-induced OSCC cell migration, implicating that CCL7 promotes cancer cell migration through CCR1 and CCR3 on OSCC cells.

Modifications:
In compartment: default
  1. TUMOR_INVASION@default map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. Reactive_stroma@default map → map TUMOR_INVASION@default map
    2. Actomyosin_contractility@default map → map TUMOR_INVASION@default map
    3. IL11@Cytosol map → map TUMOR_INVASION@default map
    4. IL6@Cytosol map → map TUMOR_INVASION@default map
    5. SATB2@Cytosol map → map TUMOR_INVASION@default map
    6. WNT7@default map → map TUMOR_INVASION@default map
    7. CCL2@Cytosol map → map TUMOR_INVASION@default map
    8. LOXL2@Cytosol map → map TUMOR_INVASION@default map
    9. STC1@Cytosol map → map TUMOR_INVASION@default map
    10. POSTN@Cytosol map → map TUMOR_INVASION@default map
    11. lactate@default map → map TUMOR_INVASION@default map
    As Catalyser: