Protein IL11 map

Identifiers
interleukin 11
HUGO:IL11 hgnc_id:HGNC:5966 HGNC:5966 ENTREZ:3589 UNIPROT:P20809

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / CYTOKINES_CHEMOKINES_PRODUCTION  map

References
CASCADE:IL1
CASCADE:TGFB
PMID:8133053
IL1a and TGFB induce gene expression and protein accamulation in fibroblasts.
PMID:23153532; PMID:25074610
Secretion of IL11 by TGF-??-stimulated cancer-associated fibroblasts (CAFs) triggers GP130/STAT3 signaling in tumor cells and induces tumor invasion..

Modifications:
In compartment: Cytosol
  1. IL11@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. IL11@Cytosol map → map CYTOKINE_CHEMOKINE_PRODUCTION@default map
    2. rIL11@Cytosol map → map IL11@Cytosol map
    3. IL11@Cytosol map → map TUMOR_INVASION@default map
    As Catalyser: