Protein POSTN map

Identifiers
HUGO:POSTN

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / MATRIX_REGULATION  map

References
CASCADE:INTEGRIN
CASCADE:TGFB
PMID:20096135
Gene expression profiling of cholangiocarcinoma-derived fibroblast reveals alterations related to tumor progression and indicates periostin as a poor prognostic marker.
PN promotes proliferation and invasion of CCA cells
Knockdown of ITG??5 attenuates PN-induced proliferation and invasion
PMID:22158103
Postn expression in fibroblast is activated by TGFB signaling, probably via SMAD.
Infiltrating tumour cells need to induce stromal POSTN expression in the secondary target organ (in this case lung) to initiate colonization. POSTN is required to allow cancer stem cell maintenance, and blocking its function prevents metastasis.

Modifications:
In compartment: Cytosol
  1. POSTN@Cytosol map
In compartment: default
  1. POSTN@default map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. POSTN@Cytosol map → map POSTN@default map
    2. rPOSTN@Cytosol map → map POSTN@Cytosol map
    3. POSTN@Cytosol map → map TUMOR_INVASION@default map
    As Catalyser:
    1. ITGA5@Cytosol map + ITGB1@Cytosol map → map ca_s4687