RNA _beta_-Catenin*_ZEB1_ZEB2* map

Identifiers
_beta_-Catenin*_ZEB1_ZEB2*
beta catenin
HUGO:CTNNB1, HGNC:2514, ENTREZ:1499, GENECARDS:GC03P041236
zinc finger E-box binding homeobox 1
HUGO:ZEB1, HGNC:11642, ENTREZ:6935, GENECARDS:GC10P031648
zinc finger E-box binding homeobox 2
HUGO:ZEB2, HGNC:14881, ENTREZ:9839, GENECARDS:GC02M145145

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map

References
PMID:22024162

r_beta_-Catenin*_ZEB1_ZEB2*@Nucleus

References
em_emtc_emtc_re1117( EMT Senescence  map ):
PMID:19931509
miR-200a downregulates ZEB2 and CTNNB1
This downregulation inhibits carcinoma cell growth, migration and invasion.
PMID:19703993
Upregulation of miR-200a decreased the expression of ZEB1 and ZEB2, with consequent increased expression of E-cadherin,
Downregulation of miR-200a in meningiomas and arachnoidal cells resulted in increased expression of beta-catenin and cyclin D1 involved in cell proliferation
PMID:20592490
PMID:22211245
CTNNB1 is direct target of MIR200A

Modifications:
In compartment: Nucleus
  1. r_beta_-Catenin*_ZEB1_ZEB2*@Nucleus map
Participates in complexes:
In compartment: Cytosol
  1. MIR200A:​_beta_-Catenin*_ZEB1_ZEB2*@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. r_beta_-Catenin*_ZEB1_ZEB2*@Nucleus map + arMIR200A@Nucleus map → map MIR200A:​_beta_-Catenin*_ZEB1_ZEB2*@Cytosol map
  2. r_beta_-Catenin*_ZEB1_ZEB2*@Nucleus map → map r_beta_-Catenin*@Nucleus map
  3. r_beta_-Catenin*_ZEB1_ZEB2*@Nucleus map → map rZEB1@Nucleus map
  4. r_beta_-Catenin*_ZEB1_ZEB2*@Nucleus map → map rZEB2@Nucleus map
As Catalyser: