ZEB1

Protein ZEB1

Identifiers
zinc finger E-box binding homeobox 1
HUGO:ZEB1, HGNC:11642, ENTREZ:6935, UNIPROT:P37275, GENECARDS:GC10P031648

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS

References
PMID:19839049
ZEB1 inhibits MIR200
PMID:21224848
Feedback loops
PMID:225147423

ZEB1@Nucleus

References
em_emtc_emtc_re11( EMT Senescence ):
PMID:28212565
Double negative feedback loop between ZEB1 and miR200
em_emtc_emtc_re22( EMT Senescence ):
PMID:10048576
The gene expressions of MMP-1, MMP-3, and MMP-9 and gelatinolytic activity of MMP-9 were significantly increased in high ETS-1 expression cells.
Low ETS-1 expression cells could not spread on a vitronectin substratum, and the phosphorylation of focal adhesion kinase was markedly impaired because of the reduced expression of integrin b3
PMID:19208835
TCF8 (ZEB1) regulates cell invasion and migration via MMP1 expression.
TCF8 is likely to be dispensable for endothelial cell motility.
One possible mechanism underlying the increased invasiveness and migration might be the up-regulated digestion of ECMs via TCF8-mediated transcriptional regulation of the gene encoding MMP1.
MMP1 induction during tube formation was significantly enhanced in Matrigel when TCF8 was silenced
PMID:21081489
MiR-200b Regulates Ets-1-associated Genes
Suppression of endogenous miR-200b induced MMP-1 and VEGFR2 expressions
Overexpression of Ets-1 did not completely reverse miR- 200b-associated MMP-1 and VEGFR2 down-regulation.
It indicates that miR-200b, apart from targeting Ets-1, might silence other target proteins involved in transcription of the indicated genes.
PMID:20589835
Our results indicate that MT1-MMP is a direct down-stream target in the Wnt signaling pathway, and that one of the ways accumulated beta-catenin contributes to colorectal carcinogenesis is by transactivating this gene.
MT1-MMP is one target gene of Lef-1/Tcf-4 (Takahashi et al, 2002)
PMID:22439866
c-Myb strongly increased the expression/activity of cathepsin D and matrix metalloproteinase (MMP) 9 and significantly downregulated MMP1.
PMID:9811054
Nuclear factor kappaB/p50 activates an element in the distal matrix metalloproteinase 1 promoter in interleukin-1beta-stimulated synovial fibroblasts.
PMID:16556862
ROS regulate MMP gene expression and activation of proenzymes. MMP-1, MMP-2, MMP-7, and MMP-9 are activated by ROS through interactions with thiol groups
em_emtc_emtc_re26( EMT Senescence ):
PMID:21051859
TCF3 (E47) is upregulated by Snail1, Snail2, Zeb1.
em_emtc_emtc_re32( EMT Senescence ):
PMID:17486063
ZEB1 represses PATJ* expression
PMID:17012742
Knock down of LIN7 results in loss of expression of PATJ*
em_emtc_emtc_re356( EMT Senescence ):
PMID:22945800
PMID:22286765
Six1 induces ZEB1 and EMT through transcriptional repression of miR200.
PMID:20706219
Feedback loop between ZEB1, ZEB2 and MIR200 family
PMID:19935649
ZEB1 inhibits expression of MIR200 family
PMID:22514743
SNAI1 represses expression of all MIR200 family members.
em_emtc_emtc_re366( EMT Senescence ):
SNAI1 inhibits miR-203
SNAI1 represses miR-203 and miR-200b expression
PMID:21159887
p53 activates expression of miR-203
PMID:20702634
Feedback loop: ZEB1 inhibits expression of MIR203 and MIR183
ZEB1 directly controls transcription of the miR-203 and miR-183 and miR-200 family genes
ZEB2 inhibits expression of MIR203
em_emtc_emtc_re375( EMT Senescence ):
TCF8 (ZEB1) is a negative regulator of angiogenesis in vitro, ex vivo, and in vivo.
em_emtc_emtc_re1136( EMT Senescence ):
PMID:24335145
??-Catenin/TCF/LEF-1 binds to the promoter of miR-183-96-182 cluster gene and thereby activates the transcription of the cluster.
em_emtc_emtc_re1198( EMT Senescence ):
Protein expression of Bmi1, Sox2, p63 was reduced after ZEB1 knockdown.
ZEB1 knockdown not only resulted in reduced invasion and metastasis, but also in reduced tumorigenicity.
ZEB1 is also necessary for the self-renewing capacity.
ZEB1 is crucial for drug resistance in pancreatic cancer cells. This supports data showing that EMT activators (Twist and Snail) confer anti-apoptotic properties
em_emtc_emtc_re1200( EMT Senescence ):
Expression of Bmi1, Sox2, p63 was reduced after ZEB1 knockdown.

Modifications:
In compartment: Nucleus

ZEB1@Nucleus

Participates in complexes:
In compartment: Nucleus

Participates in reactions:
As Reactant or Product:

As Catalyser: