Identifiers
microRNA 200a
HUGO:MIR200A, HGNC:31578, ENTREZ:406983, GENECARDS:GC01P001101
microRNA 200b
HUGO:MIR200B, HGNC:31579, ENTREZ:406984, GENECARDS:GC01P001100
microRNA 200c
HUGO:MIR200C, HGNC:31580, ENTREZ:406985, GENECARDS:GC12P007072
microRNA 141
HUGO:MIR141, HGNC:31528, ENTREZ:406933, GENECARDS:GC12P007073
microRNA 429
HUGO:MIR429, HGNC:13784, ENTREZ:554210, GENECARDS:GC01P001109
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
References
PMID:21336307
PMID:22370643
Regulation of BMI1 and JAG1
PMID:21224848
Feedback loops
PMID:225147423
References
em_emtc_emtc_re356( EMT Senescence ):
PMID:22945800
PMID:22286765
Six1 induces ZEB1 and EMT through transcriptional repression of miR200.
PMID:20706219
Feedback loop between ZEB1, ZEB2 and MIR200 family
PMID:19935649
ZEB1 inhibits expression of MIR200 family
PMID:22514743
SNAI1 represses expression of all MIR200 family members.
em_emtc_emtc_re11( EMT Senescence ):
PMID:28212565
Double negative feedback loop between ZEB1 and miR200
em_emtc_emtc_re1115( EMT Senescence ):
PMID:22311119
miR-200b regulates ZEB2 expression and thus controls metastasis in gastric cancer
em_emtc_emtc_re1118( EMT Senescence ):
PMID:20592490
The MIR200 family comprises 5 members (MIR200A, B, C, MIR141 and MIR429).
These 5 members are clustered and expressed as 2 separate polycistronic pri-miRNA transcripts, miR200B-200A-429 and miR200C-141.
These 2 transcripts are located on human chromosomes 1 and 12, respectively.