Identifiers
microRNA 200a
HUGO:MIR200A, HGNC:31578, ENTREZ:406983, GENECARDS:GC01P001101
microRNA 200b
HUGO:MIR200A
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
HMC:AVOIDING_IMMUNE_DESTRUCTION
Innate Immunity / IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS
Innate Immunity / MIRNA_TF_IMMUNOSTIMULATORY
References
PMID:20592490
The MIR200 family comprises 5 members (MIR200A, B, C, MIR141 and MIR429).
These 5 members are clustered and expressed as 2 separate polycistronic pri-miRNA transcripts, miR200B-200A-429 and miR200C-141.
These 2 transcripts are located on human chromosomes 1 and 12, respectively.
NATURAL_KILLER
CASCADE:IL12
PMID:22077060
The miRs-132, 212, and 200a were shown to be induced in human NK cells by IL-12 stimulation, which in turn target STAT4 mRNA, thereby providing a negative regulatory pathway for IL-12 signaling.
References
em_emtc_emtc_re1118( EMT Senescence ):
PMID:20592490
The MIR200 family comprises 5 members (MIR200A, B, C, MIR141 and MIR429).
These 5 members are clustered and expressed as 2 separate polycistronic pri-miRNA transcripts, miR200B-200A-429 and miR200C-141.
These 2 transcripts are located on human chromosomes 1 and 12, respectively.
em_emtc_emtc_re1117( EMT Senescence ):
PMID:19931509
miR-200a downregulates ZEB2 and CTNNB1
This downregulation inhibits carcinoma cell growth, migration and invasion.
PMID:19703993
Upregulation of miR-200a decreased the expression of ZEB1 and ZEB2, with consequent increased expression of E-cadherin,
Downregulation of miR-200a in meningiomas and arachnoidal cells resulted in increased expression of beta-catenin and cyclin D1 involved in cell proliferation
PMID:22211245
CTNNB1 is direct target of MIR200A
+ arMIR200A@Nucleus → MIR200A:_beta_-Catenin*_ZEB1_ZEB2*@Cytosol
→ arMIR200A@Nucleus
→ arMIR200A@INNATE_IMMUNE_CELL_Cytosol
+ rSTAT4@INNATE_IMMUNE_CELL_Cytosol → MIR200A:STAT4@INNATE_IMMUNE_CELL_Cytosol
→ degraded