Protein APPL2 map

Identifiers
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
HUGO:APPL2 HGNC:18242 ENTREZ:55198 UNIPROT:Q8NEU8

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / DEPENDANCE_RECEPTORS  map

References
PMID:12011067
DIP13 alpha is a mediator of the DCC apoptotic pathway
PMID:22920895

APPL2@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / DEPENDANCE_RECEPTORS  map

References
rc_re1692( Regulated Cell Death  map ):
PMID:12011067
DCC interacts with both caspase-3 and caspase-9 and drives the activation of caspase-3 through caspase-9

Modifications:
In compartment: Cytosol
  1. APPL2@Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. APPL2:​Caspase9*:​Cleaved DCC*@Cytosol map
  2. APPL2:​Cleaved DCC*:​cleaved~Caspase9*@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. APPL2:​Caspase9*:​Cleaved DCC*@Cytosol map → map APPL2:​Cleaved DCC*:​cleaved~Caspase9*@Cytosol map
  2. APPL2@Cytosol map + Cleaved DCC*@Cytosol map + Caspase9*@Cytosol map → map APPL2:​Caspase9*:​Cleaved DCC*@Cytosol map
As Catalyser:
  1. Caspase3*@Cytosol map → map cleaved~Caspase3*@Cytosol map