Simple molecule PGE2 map
PGE2@default

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / CYTOKINES_CHEMOKINES_PRODUCTION  map
 Cancer Associated Fibroblasts  map  / INFLAMMATORY_SIGNALING_PATHWAYS  map

References
CASCADE:PGE
PMID:23873014, PMID:19934056,PMID:22182446
Probably CAFS inhibit NK cells via PGE2 signaling.
addition of the PGE2 inhibitor NS398 to cocultures restored the expression of NKp44 and NKp30.
There is a correlation between PGE2 release and inhibitory functions in tumor fibroblasts.
PMID:22182446
Increased levels of PGE2 were found in cocultured supernatants from HCC-derived fibroblasts, and up-regulated expression of IDO and COX-2 were detected in these cells.
The expression of NKP30, NKG2D, granzyme B and perforin were partly restored by PGE2 inhibitor and IDO inhibitor and
the production of TNF-?? and IFN-?? were fully restored by them.

PGE2@Cytosol

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / CYTOKINES_CHEMOKINES_PRODUCTION  map

References
PMID:23873014, PMID:19934056,PMID:22182446
Probably CAFS inhibit NK cells via PGE2 signaling.
addition of the PGE2 inhibitor NS398 to cocultures restored the expression of NKp44 and NKp30.
There is a correlation between PGE2 release and inhibitory functions in tumor fibroblasts.
PMID:22182446
Increased levels of PGE2 were found in cocultured supernatants from HCC-derived fibroblasts, and up-regulated expression of IDO and COX-2 were detected in these cells.
The expression of NKP30, NKG2D, granzyme B and perforin were partly restored by PGE2 inhibitor and IDO inhibitor and
the production of TNF-?? and IFN-?? were fully restored by them.

PGE2@INNATE_IMMUNE_CELL_Cytosol

References
PMID:22025564
COX2 catalyses synthesis of PGE2 in MDSC.

Modifications:
In compartment: Cytosol
  1. PGE2@Cytosol map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. PGE2@INNATE_IMMUNE_CELL_Cytosol map
In compartment: default
  1. PGE2@default map
Participates in complexes:
In compartment: Cytosol
  1. PGE2:​PTGER2@Cytosol map
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. PGE2:​PTGER2@INNATE_IMMUNE_CELL_Membrane map
  2. PGE2:​PTGER4@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. PGE2@Cytosol map → map PGE2@default map
  2. PGE2@default map → map IMMUNE_SYSTEME_MODULATION@default map
  3. PGE2@default map + PTGER2@Cytosol map → map PGE2:​PTGER2@Cytosol map
  4. PGE2@Cytosol map → map PGE2@default map
  5. PGE2@INNATE_IMMUNE_CELL_Cytosol map → map IMMUNE_SUPRESSION@default map
  6. PGE2@default map + PTGER2@INNATE_IMMUNE_CELL_Membrane map → map PGE2:​PTGER2@INNATE_IMMUNE_CELL_Membrane map
  7. PGE2@default map + PTGER4@INNATE_IMMUNE_CELL_Membrane map → map PGE2:​PTGER4@INNATE_IMMUNE_CELL_Membrane map
  8. Arachidonic acid@INNATE_IMMUNE_CELL_Cytosol map → map PGE2@INNATE_IMMUNE_CELL_Cytosol map
  9. PGE2@INNATE_IMMUNE_CELL_Cytosol map → map PTGS2@INNATE_IMMUNE_CELL_Cytosol map
  10. PGE2@INNATE_IMMUNE_CELL_Cytosol map → map PGE2@default map
As Catalyser:
  1. gIL6@Cytosol map → map rIL6@Cytosol map
  2. gMIR149@Cytosol map → map arMIR149@Cytosol map
  3. THBS1@INNATE_IMMUNE_CELL_Cytosol map → map THBS1@default map
  4. CXCL12@TUMOR_CELL_AS_INDUCTOR map → map CXCL12@default map
  5. Adenylyl_cyclase*@INNATE_IMMUNE_CELL_Cytosol map → map Adenylyl_cyclase*@INNATE_IMMUNE_CELL_Cytosol map
  6. gCXCR4@INNATE_IMMUNE_CELL_Cytosol map → map rCXCR4@INNATE_IMMUNE_CELL_Cytosol map