Phenotype IMMUNE_SYSTEME_MODULATION map
IMMUNE_SYSTEME_MODULATION@default

References
PMID:19956757
Cancer associated fibroblasts promote tumor growth and metastasis by modulating the tumor immune microenvironment in a 4T1 murine breast cancer model
PMID:21051638
Depletion of FAP-expressing cells, which made up only 2% of all tumor cells in established Lewis lung carcinomas, caused rapid hypoxic necrosis of both cancer and stromal cells in immunogenic tumors by a process involving interferon-?? and tumor necrosis factor-??. Depleting FAP-expressing cells in a subcutaneous model of pancreatic ductal adenocarcinoma also permitted immunological control of growth. Therefore, FAP-expressing cells are a nonredundant, immune-suppressive component of the tumor microenvironment.

Modifications:
In compartment: default
  1. IMMUNE_SYSTEME_MODULATION@default map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. IL32@Cytosol map → map IMMUNE_SYSTEME_MODULATION@default map
    2. CLCF1@Cytosol map → map IMMUNE_SYSTEME_MODULATION@default map
    3. PGE2@default map → map IMMUNE_SYSTEME_MODULATION@default map
    4. IDO1@Cytosol map → map IMMUNE_SYSTEME_MODULATION@default map
    5. CYTOKINE_CHEMOKINE_PRODUCTION@default map → map IMMUNE_SYSTEME_MODULATION@default map
    6. PDL1*@Cytosol map → map IMMUNE_SYSTEME_MODULATION@default map
    7. PDL2*@Cytosol map → map IMMUNE_SYSTEME_MODULATION@default map
    8. MHC_class_II*@Cytosol map → map IMMUNE_SYSTEME_MODULATION@default map
    9. B7H3*@Cytosol map → map IMMUNE_SYSTEME_MODULATION@default map
    10. NT5E@Cytosol map → map IMMUNE_SYSTEME_MODULATION@default map
    11. OX40L*@Cytosol map → map IMMUNE_SYSTEME_MODULATION@default map
    12. S100A4@Cytosol map → map IMMUNE_SYSTEME_MODULATION@default map
    As Catalyser: