Antisense RNA MIR149 map

Identifiers
HUGO:MIR149
microRNA 149
HUGO:MIR149 HGNC:31536 ENTREZ:406941

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / CAF_INHIBITION_ANTITUMOR  map

References
CASCADE:PGE
PMID:25916550
miR-149 targets IL-6 mRNA and is downregulated in GC CAFs
miR-149 mimics significantly suppressed the stimulatory effect of CAFs on GC cell proliferation, colony forming ability, migration and invasion; conversely, miR-149 inhibitors conferred NFs the enhancing effects.
PGE2 receptor, PTGER2 and IL6, are potential targets of miR-149
PGE2 binds to EP2 and induces the hypermethylation and suppression of miR-149, reversing the downregulation of IL-6 and EP2 expression.
PMID:24272429
PMID:23665507
PMID:23377965
PMID:24206455
PMID:23453900
PMID:21145728
PMID:22902544
PMID:23550650

Modifications:
In compartment: Cytosol
  1. arMIR149@Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. IL6:​MIR149@Cytosol map
  2. MIR149:​PTGER2@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. gMIR149@Cytosol map → map arMIR149@Cytosol map
  2. rPTGER2@Cytosol map + arMIR149@Cytosol map → map MIR149:​PTGER2@Cytosol map
  3. MIR149:​PTGER2@Cytosol map → map degraded
  4. arMIR149@Cytosol map + rIL6@Cytosol map → map IL6:​MIR149@Cytosol map
  5. IL6:​MIR149@Cytosol map → map degraded
  6. arMIR149@Cytosol map → map NEGATIVE_REGULATORS OF_CAF@Cytosol map
As Catalyser:
  1. rE2F1@Nucleus map → map E2F1@Nucleus map
  2. rAKT1@Nucleus map → map AKT1@Cytosol map
  3. rCDKN1A@Nucleus map → map CDKN1A@Cytosol map