Identifiers
epidermal growth factor receptor
HUGO:EGFR hgnc_id:HGNC:3236 HGNC:3236 ENTREZ:1956 UNIPROT:P00533
HUGO:EGFR, HGNC:3236, ENTREZ:1956, UNIPROT:P00533, GENECARDS:GC07P055054
"epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)", ERBB
HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFRHUGO:EGFR

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts   / GROWTH_FACTORS_SIGNALING_PATHWAYS 
 EMT Senescence   / EMT_REGULATORS 
 EMT Senescence   / ECM 

References
PMID:25987127; PMID:23010081
Celecoxib (specific COX-2 inhibitor)increases EGF signaling in colon tumor associated fibroblasts, modulating EGFR expression and degradation
and increase colon TAFs proliferation in the presence of EGF.
Also it induces neo-expression and release of Amphiregulin (AREG), a well known EGFR agonist
PMID:20430953 PMID:28513565

References
s_wnc1_re37( Survival  ):
PMID:18372913
PAR1 activates EGFR
PMID:16525676

1. EGFR@Cytoplasm

1. EGFR@Cytosol

1. EGFR@Membrane

1. EGFR:​HB-EGF*:​HER2*@Cytoplasm

1. EGFR:​ERBB*@Cytosol

1. EGFR:​ERBB*@Membrane

1. EGFR@Cytosol + ERBB*@Cytosol → EGFR:​ERBB*@Cytosol
2. rEGFR@Cytosol → EGFR@Cytosol
3. EGFR@Cytosol → degraded
4. EGFR:​ERBB*@Cytosol → Fibroblast_proliferation@Cytosol
5. EGFR family*@Cytosol → EGFR@Cytosol
6. EGFR@Membrane + ERBB*@Membrane → EGFR:​ERBB*@Membrane
7. EGFR:​ERBB*@Membrane → MAPK_PATHWAYS@Membrane
8. EGFR:​ERBB*@Membrane → PI3K_PATHWAY@Membrane
9. EGFR:​ERBB*@Membrane → PLCG_PATHWAYS@Membrane
10. EGFR:​ERBB*@Membrane → JAK/STAT_PATHWAY@Membrane
11. EGFR:​HB-EGF*:​HER2*@Cytoplasm → PI3K AKT MTOR pathway@Cytoplasm
12. HB-EGF*@default + EGFR@Cytoplasm + HER2*@Cytoplasm → EGFR:​HB-EGF*:​HER2*@Cytoplasm

1. GRB2@Cytosol → GRB2@Cytosol
2. SHC1@Cytosol → SHC1|​pho@Cytosol