Protein trIL1A map

Identifiers
interleukin 1 alpha
HUGO:IL1A hgnc_id:HGNC:5991 HGNC:5991 ENTREZ:3552 UNIPROT:P01583

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / INFLAMMATORY_SIGNALING_PATHWAYS  map

References
CASCADE:IL1
PMID:19937793
Interleukin-1alpha was an inducer of CCL7 secretion by CAF.
PMID:21847358
IL-1?? was established as the initiator of the enhanced production of inflammatory factors through the binding of IL-1?? to IL-1 receptor 1 (IL-1R1) expressed predominantly by CAFs.
IL1A upregulates expression of IL6, CCL20, CXCL8, COX2 in CAFs.
IL-1?? Expression Levels in prostate cancer Tissue Correlated to Poor Clinical Outcome
PMID:8910423
IL1A signaling induces ERK1/2 activity and AP1 activation and controls activation of RPS6KA1.
In tnfr1o/tnfr2o fibroblasts, hIL-1??, but not mTnf??, activated Raf-1, Raf-B, Mekk, and Mek-1.
Also IL1A induces NFkB pathway

trIL1A@default

References
ca_re283( Cancer Associated Fibroblasts  map ):
PMID:16713974
TLR2 activates (induces phosphorylation of) ERKs, JNKs, and p38 rapidly and transiently in control macrophages.
This activation is inhibited by IFNG signaling.
PMID:11438547, PMID:24378531
Both TNFR1 and TNFR2 signaling pathways induce JNK activation and downstrean c-jun phosphorylation.
ca_re410( Cancer Associated Fibroblasts  map ):
CASCADE:LIF
PMID:22595692
The structure of receptors of IL6 like cytokines

Modifications:
In compartment: default
  1. trIL1A@default map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
      As Catalyser:
      1. CCL7@Cytosol map → map CCL7@default map
      2. gCCL20@Cytosol map → map rCCL20@Cytosol map
      3. gCXCL8@Cytosol map → map rCXCL8@Cytosol map
      4. gIL6@Cytosol map → map rIL6@Cytosol map
      5. gPTGS2@Cytosol map → map rPTGS2@Cytosol map
      6. gTIMP1@Cytosol map → map rTIMP1@Cytosol map
      7. JNK*@Cytosol map → map JNK*|​pho|​active@Cytosol map
      8. ERK1/2*@Cytosol map → map ERK1/2*|​pho@Cytosol map
      9. IL1R1:​IL1RAP@Cytosol map + MYD88@Cytosol map + IRAK4@Cytosol map → map IL1R1:​IL1RAP:​IRAK4:​MYD88@Cytosol map
      10. gLIF@Cytosol map → map rLIF@Cytosol map
      11. gIL11@Cytosol map → map rIL11@Cytosol map